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  • © 2014

Protein Conformational Dynamics

  • Covering both the description of widely used theoretical approaches and the applications of these methods in the study of protein dynamics
  • A thorough and extensive exploration and description of recent advances in the computational study of protein dynamics
  • Manifests the important role of the dynamic personalities of biological molecules in a variety of significant biological processes
  • Includes supplementary material: sn.pub/extras

Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 805)

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Table of contents (18 chapters)

  1. Front Matter

    Pages i-xii
  2. Protein Folding Simulations by Generalized-Ensemble Algorithms

    • Takao Yoda, Yuji Sugita, Yuko Okamoto
    Pages 1-27
  3. Application of Markov State Models to Simulate Long Timescale Dynamics of Biological Macromolecules

    • Lin-Tai Da, Fu Kit Sheong, Daniel-Adriano Silva, Xuhui Huang
    Pages 29-66
  4. Generative Models of Conformational Dynamics

    • Christopher James Langmead
    Pages 87-105
  5. The Joys and Perils of Flexible Fitting

    • Niels Volkmann
    Pages 137-155
  6. Exploiting Protein Intrinsic Flexibility in Drug Design

    • Suryani Lukman, Chandra S. Verma, Gloria Fuentes
    Pages 245-269
  7. Molecular Dynamics Simulation of Membrane Proteins

    • Jingwei Weng, Wenning Wang
    Pages 305-329
  8. Molecular Dynamics Simulations of F1-ATPase

    • Yuko Ito, Mitsunori Ikeguchi
    Pages 411-440
  9. Chemosensorial G-proteins-Coupled Receptors: A Perspective from Computational Methods

    • Francesco Musiani, Giulia Rossetti, Alejandro Giorgetti, Paolo Carloni
    Pages 441-457
  10. Back Matter

    Pages 459-488

About this book

This book discusses how biological molecules exert their function and regulate biological processes, with a clear focus on how conformational dynamics of proteins are critical in this respect. In the last decade, the advancements in computational biology, nuclear magnetic resonance including paramagnetic relaxation enhancement, and fluorescence-based ensemble/single-molecule techniques have shown that biological molecules (proteins, DNAs and RNAs) fluctuate under equilibrium conditions. The conformational and energetic spaces that these fluctuations explore likely contain active conformations that are critical for their function. More interestingly, these fluctuations can respond actively to external cues, which introduces layers of tight regulation on the biological processes that they dictate. A growing number of studies have suggested that conformational dynamics of proteins govern their role in regulating biological functions, examples of this regulation can be found in signal transduction, molecular recognition, apoptosis, protein / ion / other molecules translocation and gene expression.

 

On the experimental side, the technical advances have offered deep insights into the conformational motions of a number of proteins. These studies greatly enrich our knowledge of the interplay between structure and function.

 

On the theoretical side, novel approaches and detailed computational simulations have provided powerful tools in the study of enzyme catalysis, protein / drug design, protein / ion / other molecule translocation and protein folding/aggregation, to name but a few. This work contains detailed information, not only on the conformational motions of biological systems, but also on the potential governing forces of conformational dynamics (transient interactions, chemical and physical origins, thermodynamic properties). New developments in computational simulations will greatly enhance our understanding of how these molecules function invarious biological events.

Editors and Affiliations

  • Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, People's Republic of China

    Ke-li Han, Ming-jun Yang

  • The Scripps Research Institute, La Jolla, USA

    Xin Zhang

Bibliographic Information

  • Book Title: Protein Conformational Dynamics

  • Editors: Ke-li Han, Xin Zhang, Ming-jun Yang

  • Series Title: Advances in Experimental Medicine and Biology

  • DOI: https://doi.org/10.1007/978-3-319-02970-2

  • Publisher: Springer Cham

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2014

  • Hardcover ISBN: 978-3-319-02969-6Published: 30 January 2014

  • Softcover ISBN: 978-3-319-35389-0Published: 27 August 2016

  • eBook ISBN: 978-3-319-02970-2Published: 20 January 2014

  • Series ISSN: 0065-2598

  • Series E-ISSN: 2214-8019

  • Edition Number: 1

  • Number of Pages: XII, 488

  • Number of Illustrations: 21 b/w illustrations, 102 illustrations in colour

  • Topics: Biomedicine general, Protein Science, Computer Appl. in Life Sciences

Buy it now

Buying options

eBook USD 129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access