Short communicationMeasuring dissolved oxygen to track erythroid differentiation of hematopoietic progenitor cells in culture
References (23)
- et al.
The potential of human peripheral blood derived CD34+ cells for ex vivo red blood cell production
J. Biotechnol.
(2009) - et al.
Copper deficiency alters cell bioenergetics and induces mitochondrial fusion through up-regulation of MFN2 and OPA1 in erythropoietic cells
Biochem. Biophys. Res. Commun.
(2013) - et al.
Modeling pO(2) distributions in the bone marrow hematopoietic compartment. II. Modified Kroghian models
Biophys. J.
(2001) - et al.
Proof of principle for transfusion of in vitro-generated red blood cells
Blood
(2011) - et al.
Metabolic adaptation during erythropoietin-mediated terminal differentiation of mouse erythroid cells
Blood
(1991) - et al.
Characterization of mitochondrial and extra-mitochondrial oxygen consuming reactions in human hematopoietic stem cells. Novel evidence of the occurrence of NAD(P)H oxidase activity
J. Biol. Chem.
(2005) - et al.
Hypoxia alters progression of the erythroid program
Exp. Hematol.
(2008) - et al.
Enhanced erythroid cell differentiation in hypoxic condition is in part contributed by miR-210
Blood Cells Mol. Dis.
(2013) - et al.
Blood cell manufacture: current methods and future challenges
Trends Biotechnol.
(2009) - et al.
Low oxygen concentration as a general physiologic regulator of erythropoiesis beyond the EPO-related downstream tuning and a tool for the optimization of red blood cell production ex vivo
Exp. Hematol.
(2009)
The rate of oxygen utilization by cells
Free Radic. Biol. Med.
(2011)
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Metabolic profiling of hematopoietic stem and progenitor cells during proliferation and differentiation into red blood cells
2016, New BiotechnologyCitation Excerpt :Thus, the higher pH in SF cultures in late proliferation phase may have contributed to the more mature surface marker profile. Previous studies have demonstrated a distinct metabolic profile during during HSPC differentiation into RBCs [28–30]. Generally, proliferative cells with a very high growth rate rely on glycolysis for energy, while differentiating cells switch to more efficient energy production through OXPHOS [28,31].
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