Circadian Rhythms and Their Impact on Aging

1. Front Matter

   Pages i-xiii

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2. Circadian Dysregulation and Melatonin Rhythm Suppression in the Context of Aging

   • Russel J. Reiter, Sergio A. Rosales-Corral, Dun Xian Tan, Moises Alatorre-Jimenez, Carlos Lopez

   Pages 1-25

3. Pulmonary Diseases, a Matter of Time

   • Cecilia G. Sanchez

   Pages 27-63

4. Circadian Regulation of Bone

   • Sifat Maria, Paula A. Witt-Enderby

   Pages 65-82

5. Aging and the Circadian Control of the Gastrointestinal System: From the Brain to the Gut Microbiome (and Back)

   • Vincent M. Cassone, Jiffin K. Paulose, Clifford E. Harpole

   Pages 83-101

6. Circadian System and Aging in Rodent Models

   • Andrey V. Panchenko, Ekaterina A. Gubareva, Vladimir N. Anisimov

   Pages 103-128

7. The Circadian System and Aging of Drosophila

   • Jadwiga M. Giebultowicz

   Pages 129-145

8. Circadian Control of Mitochondrial Dynamics and Its Implication in Aging

   • David Jacobi, Florian Atger, Chih-Hao Lee

   Pages 147-161

9. Circadian Rhythms and Proteostasis in Aging

   • Audrey Desvergne, Bertrand Friguet

   Pages 163-191

10. Circadian Clocks and mTOR Signaling

    • Richa Gupta, Roman V. Kondratov

    Pages 193-210

11. Aging and the Biological Clock

    • Michael Judge, James Griffith, Jonathan Arnold

    Pages 211-234

12. Developing Circadian Therapeutics Against Age-Related Metabolic Decline

    • Kazunari Nohara, Seung-Hee Yoo, Zheng Chen

    Pages 235-268

13. The Possible Role of Epigenetics in the Memory Impairment Elicited by Circadian Rhythm Disruption

    • Scott H. Deibel, Robert J. McDonald

    Pages 269-304

14. Circadian Sleep-Wake Activity Patterns During Aging

    • Katie L. Stone, Gregory J. Tranah

    Pages 305-321

15. Effects of Physical Activity on Circadian Rhythms in the Elderly

    • Nicolas Bessot

    Pages 323-335

16. Back Matter

    Pages 337-361

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Biological rhythms time the ebb and flow of virtually every physiological process, and their mutual coordination guarantees the integrity of the organism over space and time. Aging leads to the disintegration of this coordination, as well as to changes in the amplitude and/or frequency of the underlying rhythms. The results of this are accelerated loss of health during aging, and in experimental model systems curtailed lifespan occurs. This book will examine the machinery that constitutes circadian systems and how they impact physiologic processes. It will also discuss how disturbances of circadian rhythms can lead to complex diseases associated with aging. Much of this treatment will focus on metabolism and genome stability. Importantly, the chapters in this book will encompass work in several different models, in addition to human. The book will conclude with a discussion of modeling approaches to biologic cycles and chronotherapy, for future research and translation.

• Circadian rhythms
• Healthy aging
• Diseases of aging
• Metabolism
• Genome stability

• Tulane Center for Aging, Department of Medicine, School of Medicine, Tulane University, New Orleans, USA

  S. Michal Jazwinski

• Department of Structural and Cellular Biology, School of Medicine, Tulane University, New Orleans, USA

  Victoria P Belancio, Steven M Hill

S. Michal Jazwinski, Ph.D. is the John W. Deming, M.D. Regents Chair in Aging, Professor of Medicine, and Director of the Tulane Center for Aging at Tulane University.  His research on various aspects of aging has been funded by the National Institute on Aging (NIH) and private foundations, and it spans over thirty years.  It includes genetic studies in model organisms and multidisciplinary studies in humans.

Victoria P. Belancio, Ph.D. is an Associate Professor of Structural and Cellular Biology at Tulane University. Her research on retrotransposon-associated genomic instability has been funded by the National Institute on Aging (NIH) and private foundations. It includes projects investigating how circadian disruption impacts DNA damage induced by retroelements and whether this damage influences mammalian aging.

Steven M. Hill, Ph.D. is the Edmond and Lily Safra Chair for Breast Cancer Research, Professor of Structural & Cellular Biology, and Director of the Tulane Center for Circadian Biology at Tulane University.  His research on various aspects of circadian biology and breast cancer has been funded by the National Cancer Institute (NIH), the Army Department of Defense Breast Cancer Program, and private foundations, and spans over 25 years.   His recent research efforts have focused on the impact of circadian/melatonin disruption by light at night on human breast cancer progression, metastasis, and drug resistance.

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