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  • © 2015

Lipids in Protein Misfolding

Editors:

  • Explains how protein misfolding is an important biological phenomenon underlying over 20 major human diseases
  • Shows that Lipids importantly influence protein misfolding and amyloid diseases
  • Provides an up-to-date analysis of the roles of lipids in protein misfolding
  • Discusses a wide array of proteins, lipids and their modes of interaction
  • Focusses on the biophysical and structural properties of the interacting partners
  • Complements the small collection of books on this topic in this rapidly developing field

Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 855)

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Softcover Book USD 169.99
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Table of contents (10 chapters)

  1. Front Matter

    Pages i-xiii
  2. Lipids in Amyloid-β Processing, Aggregation, and Toxicity

    • Isabel Morgado, Megan Garvey
    Pages 67-94
  3. Role of Cholesterol and Phospholipids in Amylin Misfolding, Aggregation and Etiology of Islet Amyloidosis

    • Sanghamitra Singh, Saurabh Trikha, Diti Chatterjee Bhowmick, Anjali A. Sarkar, Aleksandar M. Jeremic
    Pages 95-116
  4. Intrinsic Stability, Oligomerization, and Amyloidogenicity of HDL-Free Serum Amyloid A

    • Wilfredo Colón, J. Javier Aguilera, Saipraveen Srinivasan
    Pages 117-134
  5. Interactions of Lipid Membranes with Fibrillar Protein Aggregates

    • Galyna Gorbenko, Valeriya Trusova, Mykhailo Girych, Emi Adachi, Chiharu Mizuguchi, Hiroyuki Saito
    Pages 135-155
  6. The Role of Lipid in Misfolding and Amyloid Fibril Formation by Apolipoprotein C-II

    • Timothy M. Ryan, Yee-Foong Mok, Geoffrey J. Howlett, Michael D. W. Griffin
    Pages 157-174
  7. Role of Syndecans in Lipid Metabolism and Human Diseases

    • Elena I. Leonova, Oxana V. Galzitskaya
    Pages 241-258
  8. Back Matter

    Pages 259-260

About this book

​Protein conversion from a water-soluble native conformation to the insoluble aggregates and fibrils, which can deposit in amyloid plaques, underlies more than 20 human diseases, representing a major public health problem and a scientific challenge. Such a conversion is called protein misfolding. Protein misfolding can also involve errors in the topology of the folded proteins and their assembly in lipid membranes. Lipids are found in nearly all amyloid deposits in vivo, and can critically influence  protein misfolding in vitro and in vivo in many different ways. This book focuses on recent advances in our understanding of the role of lipids in modulating the misfolding of various proteins. The main emphasis is on the basic biophysical studies that address molecular basis of protein misfolding and amyloid formation, and the role of lipids in this complex process.

Editors and Affiliations

  • Dept. of Physiology and Biophysics, Boston University School of Medicine, Boston, USA

    Olga Gursky

Bibliographic Information

  • Book Title: Lipids in Protein Misfolding

  • Editors: Olga Gursky

  • Series Title: Advances in Experimental Medicine and Biology

  • DOI: https://doi.org/10.1007/978-3-319-17344-3

  • Publisher: Springer Cham

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2015

  • Hardcover ISBN: 978-3-319-17343-6Published: 21 July 2015

  • Softcover ISBN: 978-3-319-37205-1Published: 15 October 2016

  • eBook ISBN: 978-3-319-17344-3Published: 06 July 2015

  • Series ISSN: 0065-2598

  • Series E-ISSN: 2214-8019

  • Edition Number: 1

  • Number of Pages: XIII, 260

  • Number of Illustrations: 26 b/w illustrations, 57 illustrations in colour

  • Topics: Protein Structure, Biomedicine general, Bioorganic Chemistry

Buy it now

Buying options

Softcover Book USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access