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In Vivo Reprogramming in Regenerative Medicine

  • Book
  • © 2017

Overview

Editors:
  1. Açelya Yilmazer

    1. Biomedical Engineering Department, Ankara University, Tandogan, Turkey

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  • Reviews the most relevant in vivo reprogramming studies, offering a critical assessment of this potentially powerful technology
  • Explores preclinical studies on animal models providing groundwork for researchers and clinicians to direct the future of in vivo reprogramming and its approaches to clinical settings
  • Contributors culled from top institutions worldwide provide international perspective and expertise

Part of the book series: Stem Cell Biology and Regenerative Medicine (STEMCELL)

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Table of contents (7 chapters)

  1. Front Matter

    Pages i-xvii
    Download chapter PDF

  2. Introduction to In Vivo Cell Reprogramming Technology

    • Cansu Gurcan, Hadiseh Taheri, Açelya Yilmazer
    Pages 1-10

  3. In Vivo Reprogramming for Regenerating Insulin-Secreting Cells

    • Jiaqi Lu, Qiao Zhou
    Pages 11-29

  4. Direct Reprogramming to Beta Cells

    • Jonathan M. W. Slack
    Pages 31-44

  5. In Vivo Lineage Reprogramming of Fibroblasts to Cardiomyocytes for Heart Regeneration

    • Li Wang, Jiandong Liu, Li Qian
    Pages 45-63

  6. In Vivo Cell Reprogramming to Pluripotency

    • Irene de Lázaro
    Pages 65-82

  7. In Vivo Reprogramming Towards Pluripotency for Tissue Repair and Regeneration

    • Irene de Lázaro, Kostas Kostarelos
    Pages 83-98

  8. Challenges and Future Perspectives for In Vivo Reprogramming Technology

    • Hadiseh Taheri, Cansu Gurcan, Açelya Yilmazer
    Pages 99-103
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Keywords

About this book

This new volume reviews current progress on different approaches of in vivo reprogramming technology. Leaders in the field discuss how in vivo cell lineage reprogramming can be used for tissue repair and regeneration in different organs, including brain, spinal cord, pancreas, liver and heart. Recent studies on in vivo cell reprogramming towards pluripotency are reviewed; examples are given to show its potential in regenerative medicine. In each chapter, the regenerative potential of different in vivo reprogramming approaches is discussed in detail. More specifically, how different tissue failures or damages can be treated with this technology is explained. Examples from various animal models are given and the regenerative potential of in vivo reprogramming is compared to that of cell transplantation studies. The last chapter discusses current challenges of these preclinical studies and gives suggestions in order to improve the current strategies. Future directions are indicated for the transition of in vivo reprogramming technology to clinical settings. This is among the first books in the literature which specifically focuses on the in vivo reprogramming technology in regenerative medicine and these chapters collectively cover one of the most important and exciting topics of regenerative medicine.

Editors and Affiliations

  • Biomedical Engineering Department, Ankara University, Tandogan, Turkey

    Açelya Yilmazer

About the editor

Dr. Açelya Yilmazer is as an assistant professor at the Biomedical Engineering Department and the vice director of the Stem Cell Institute of Ankara University. After receiving a BSc in Biology from the Middle East Technical University, she completed her MSc degree in Cancer Immunotherapy at the University of Nottingham and obtained her PhD in the Nanomedicine Lab based in the School of Pharmacy, University College London. She has been selected as the Best Young Investigator in Turkey by the Turkish Society of Medical Biology and Genetics. Her research laboratory focuses on cell reprogramming technologies and development of novel nanomaterial systems for directing cell fate. She is a member of the International Society of Stem Cell Research and the Biomaterials and Tissue Engineering Society of Turkey. 

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