Editors:
Provides a comprehensive view of cell death
Details the role of cell death in lymphocyte homeostasis, neuronal function, metabolism, and the DNA damage response
Discusses the potential promise of targeted therapies aimed at interdicting cell death machineries
Buy it now
Buying options
Tax calculation will be finalised at checkout
Other ways to access
This is a preview of subscription content, log in via an institution to check for access.
Table of contents (12 chapters)
-
Front Matter
-
Back Matter
About this book
Beginning from centuries of anecdotal descriptions of cell death, such as those on the development of the midwife toad in 1842 by Carl Vogt, to modern-day investigations of cell death as a biological discipline, it has become accepted that cell death in multicellular organisms is a normal part of life. This book provides a comprehensive view of cell death, from its mechanisms of initiation and execution, to its implication in human disease and therapy.
Physiological cell death plays critical roles in almost all aspects of biology, and the book details its roles in lymphocyte homeostasis, neuronal function, metabolism, and the DNA damage response. When physiological cell death goes awry, diseases can arise, and cancer is presented as a central paradigm for the consequences of derangements in the interplay between cell survival and cell death. At the same time, the potential promise of targeted therapies aimed at interdicting cell death machineries are also discussed extensively. The molecular mechanisms that underlie apoptotic cell death are illustrated from the perspectives of both the intrinsic, mitochondrial apoptotic pathway and the extrinsic, death receptor pathway. Key players in these pathways, such as the Bcl2 family proteins, cytochrome c, Apaf-1, caspases, death receptor adapter proteins, and inhibitor of apoptosis proteins, are presented from both functional and structural angles. Until only a few years ago, programmed cell death has been considered essentially synonymous with apoptosis. However, we now know that programmed cell death can also take other forms such as necrosis or necroptosis, and to this end, the mechanisms that underlie programmed necrosis in development and host defense are illustrated. The past twenty plus years have seen an incredible growth of research in cell death, with one breakthrough after another, and the legacy still goes on with constant new surprises and findings. Long live cell death!
Reviews
From the book reviews:
“This new book comprises reviews of primary studies that elucidate apoptotic pathways in specialized cells and suggest points of intervention for the treatment of various cancers. … Summing Up: Highly recommended. Upper-division undergraduates through professionals.” (S. K. Sommers Smith, Choice, Vol. 51 (11), August, 2014)
Editors and Affiliations
-
Dept. of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, USA
Hao Wu
About the editor
Bibliographic Information
Book Title: Cell Death
Book Subtitle: Mechanism and Disease
Editors: Hao Wu
DOI: https://doi.org/10.1007/978-1-4614-9302-0
Publisher: Springer New York, NY
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer Science+Business Media New York 2014
Hardcover ISBN: 978-1-4614-9301-3Published: 14 November 2013
Softcover ISBN: 978-1-4939-4325-8Published: 23 August 2016
eBook ISBN: 978-1-4614-9302-0Published: 19 November 2013
Edition Number: 1
Number of Pages: XII, 272
Number of Illustrations: 4 b/w illustrations, 42 illustrations in colour
Topics: Cell Biology, Cell Physiology, Receptors, Apoptosis, Biomedicine general