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Animal Cell Culture

  • Book
  • © 2015

Overview

Editors:
  1. Mohamed Al-Rubeai

    1. University College Dublin, Dublin, Ireland

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  • This is a book designed specifically to provide powerful research opportunities for those interested in perusing work in large scale production of stem cells for clinical application
  • This book is specially formatted so that it is not only a source on stem cell biology and therapeutic application but also a good foundation for understanding basic regenerative medicine
  • Contributions by leading international investigators from wide backgrounds/interests and geographical locations
  • Includes supplementary material: sn.pub/extras

Part of the book series: Cell Engineering (CEEN, volume 9)

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Table of contents (23 chapters)

  1. Front Matter

    Pages i-xii
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  2. Cell Line Development

    • Hansjoerg Hauser
    Pages 1-25

  3. Transient Recombinant Protein Expression in Mammalian Cells

    • Volker Jäger, Konrad Büssow, Thomas Schirrmann
    Pages 27-64

  4. Production of Antibodies in Hybridoma and Non-hybridoma Cell Lines

    • Susan McDonnell
    Pages 65-88

  5. Bioreactors for Mammalian Cells

    • R. Pörtner
    Pages 89-135

  6. Mass Transfer and Mixing Across the Scales in Animal Cell Culture

    • Alvin W. Nienow
    Pages 137-167

  7. Hydrodynamic Damage to Animal Cells

    • Jeffrey J. Chalmers, Ningning Ma
    Pages 169-183

  8. Monitoring of Cell Culture

    • Sebastian Schwamb, Robert Puskeiler, Philipp Wiedemann
    Pages 185-221

  9. Serum and Protein Free Media

    • Michael Butler
    Pages 223-236

  10. Glycosylation in Cell Culture

    • Maureen Spearman, Michael Butler
    Pages 237-258

  11. Modelling of Mammalian Cell Cultures

    • Nishikant P. Shirsat, Niall J. English, Brian Glennon, Mohamed Al-Rubeai
    Pages 259-326

  12. Mammalian Cell Line Selection Strategies for High-Producers

    • Darrin Kuystermans, Mohamed Al-Rubeai
    Pages 327-372

  13. Building a Cell Culture Process with Stable Foundations: Searching for Certainty in an Uncertain World

    • Peter M. O’Callaghan, Andrew J. Racher
    Pages 373-406

  14. Perfusion Processes

    • Véronique Chotteau
    Pages 407-443

  15. Single-Use Bioreactors for Animal and Human Cells

    • Stephan C. Kaiser, Matthias Kraume, Dieter Eibl, Regine Eibl
    Pages 445-500

  16. An Overview of Cell Culture Engineering for the Insect Cell-Baculovirus Expression Vector System (BEVS)

    • Laura A. Palomares, Mauricio Realpe, Octavio T. Ramírez
    Pages 501-519

  17. Metabolic Flux Analysis: A Powerful Tool in Animal Cell Culture

    • João V. Sá, Tiago M. Duarte, Manuel J. T. Carrondo, Paula M. Alves, Ana P. Teixeira
    Pages 521-539

  18. Cell Immobilization for the Production of Viral Vaccines

    • Ana Carina Silva, António Roldão, Ana Teixeira, Paulo Fernandes, Marcos F. Q. Sousa, Paula M. Alves
    Pages 541-563

  19. Cell Engineering for Therapeutic Protein Production

    • Eric Baek, Che Lin Kim, Jin Hyoung Park, Gyun Min Lee
    Pages 565-590

  20. Proteomics in Cell Culture: From Genomics to Combined ‘Omics for Cell Line Engineering and Bioprocess Development

    • Kelley Heffner, Christian Schroeder Kaas, Amit Kumar, Deniz Baycin-Hizal, Michael Betenbaugh
    Pages 591-614
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Keywords

About this book

​Animal cells are the preferred “cell factories” for the production of complex molecules and antibodies for use as prophylactics, therapeutics or diagnostics. Animal cells are required for the correct post-translational processing (including glycosylation) of biopharmaceutical protein products. They are used for the production of viral vectors for gene therapy. Major targets for this therapy include cancer, HIV, arthritis, cardiovascular and CNS diseases and cystic fibrosis. Animal cells are used as in vitro substrates in pharmacological and toxicological studies. This book is designed to serve as a comprehensive review of animal cell culture, covering the current status of both research and applications. For the student or R&D scientist or new researcher the protocols are central to the performance of cell culture work, yet a broad understanding is essential for translation of laboratory findings into the industrial production.  Within the broad scope of the book, each topic is reviewed authoritatively by experts in the field to produce state-of-the-art collection of current research. A major reference volume on cell culture research and how it impacts on production of biopharmaceutical proteins worldwide, the book is essential reading for everyone working in cell culture and is a recommended volume for all biotechnology libraries.

Editors and Affiliations

  • University College Dublin, Dublin, Ireland

    Mohamed Al-Rubeai

Bibliographic Information

  • Book Title: Animal Cell Culture

  • Editors: Mohamed Al-Rubeai

  • Series Title: Cell Engineering

  • DOI: https://doi.org/10.1007/978-3-319-10320-4

  • Publisher: Springer Cham

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer International Publishing Switzerland 2015

  • Hardcover ISBN: 978-3-319-10319-8Published: 09 December 2014

  • Softcover ISBN: 978-3-319-35452-1Published: 23 August 2016

  • eBook ISBN: 978-3-319-10320-4Published: 28 November 2014

  • Series ISSN: 1389-6946

  • Series E-ISSN: 2542-9515

  • Edition Number: 1

  • Number of Pages: XII, 763

  • Number of Illustrations: 33 b/w illustrations, 73 illustrations in colour

  • Topics: Biomedicine general, Cell Biology, Stem Cells, Cell Culture

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