Modern Tools of Biophysics

1. Front Matter

   Pages i-ix

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2. Wave Theory of Image Formation in a Microscope: Basic Theory and Experiments

   • Leighton T. Izu, James Chan, Ye Chen-Izu

   Pages 1-29

3. Recording of Ionic Currents Under Physiological Conditions: Action Potential-Clamp and ‘Onion-Peeling’ Techniques

   • Ye Chen-Izu, Leighton T. Izu, Bence Hegyi, Tamás Bányász

   Pages 31-48

4. Patch Clamp Technique and Applications

   • Chao-Yin Chen

   Pages 49-64

5. Structural Insights from Membrane Small-Angle X-ray Diffraction with Anomalous X-ray Scattering

   • Robert H. Fairclough, Thomas E. Lee

   Pages 65-80

6. Computer Simulations and Nonlinear Dynamics of Cardiac Action Potentials

   • Daisuke Sato

   Pages 81-107

7. Hemoglobin and Myoglobin Contribution to the NIRS Signal in Skeletal Muscle

   • Benjamin Chatel, David Bendahan, Thomas Jue

   Pages 109-117

8. Back Matter

   Pages 119-122

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Handbook of Modern Biophysics brings current biophysics topics into focus, so that biology, medical, engineering, mathematics, and physical-science students or researchers can learn fun¬damental concepts and the application of new techniques in addressing biomedical challenges. Chapters will develop the conceptual framework of the physics formalism and illustrate the biomedical applica¬tions. With the addition of problem sets, guides to further study, and references, the interested reader can continue to independently explore the ideas presented.Volume 5: Modern Tools of Biophysics
Editor: Thomas Jue, PhD
In Modern Tools of Biophysics, a group of prominent professors have provided insights into the tools used in  biophysics  with respect to the following topics:

• Wave Theory of Image Formation in a Microscope: Basic Theory and Experiments
  
• Computer Simulations and Nonlinear Dynamics of Cardiac Action Potentials
  
• Myoglobin and Hemoglobin Contribution to the NIRS Signal in Muscle
  
• Anomalous Low Angle X-Ray Scattering of Membrane with Lanthanides
  
• Recording of Ionic Currents under Physiological Conditions—Action Potential-Clamping and “Onion-Peeling” Techniques
  
• Patch Clamp Technique and Applications
  

About the Editor

Thomas Jue is a Professor in the Department of Biochemistry and Molecular Medicine at the University of California, Davis. He is an internationally recognized expert in developing and applying magnetic resonance techniques to study animal as well as human physiology in vivo and has published extensively in the field of magnetic resonance spectroscopy and imaging, near-infrared spectroscopy, bioenergetics, cardiovascular regulation, exercise, and marine biology. He served as a Chair of the Biophysics Graduate Group Program at UC Davis, where he started to develop scholarly approaches to educate graduate students with a balance of physical-science/mathematics formalism and biomedical perspective in order to promote interest at the interface of physical science, engineering, mathematics, biology, and medicine.  He continues to develop the biophysics curriculum, and the Handbook of Modern Biophysics represents an aspect of that effort.

• Rosetta
• diffraction
• lanthanides
• microscopy
• non-linear optics

• Department of Biochemistry and Molecular Medicine, University of California, Davis, Davis, USA

  Thomas Jue

Thomas Jue is a Professor in the Department of Biochemistry and Molecular Medicine at the University of California, Davis. He is an internationally recognized expert in developing and applying magnetic resonance techniques to study animal as well as human physiology in vivo and has published extensively in the field of magnetic resonance spectroscopy and imaging, near-infrared spectroscopy, bioenergetics, cardiovascular regulation, exercise, and marine biology. He served as a Chair of the Biophysics Graduate Group Program at UC Davis, where he started to develop scholarly approaches to educate graduate students with a balance of physical-science/mathematics formalism and biomedical perspective in order to promote interest at the interface of physical science, engineering, mathematics, biology, and medicine. He continues to develop the biophysics curriculum, and the Handbook of Modern Biophysics represents an aspect of that effort.

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