In Vivo Reprogramming in Regenerative Medicine

1. Front Matter

   Pages i-xvii

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2. Introduction to In Vivo Cell Reprogramming Technology

   • Cansu Gurcan, Hadiseh Taheri, Açelya Yilmazer

   Pages 1-10

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3. In Vivo Reprogramming for Regenerating Insulin-Secreting Cells

   • Jiaqi Lu, Qiao Zhou

   Pages 11-29

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4. Direct Reprogramming to Beta Cells

   • Jonathan M. W. Slack

   Pages 31-44

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5. In Vivo Lineage Reprogramming of Fibroblasts to Cardiomyocytes for Heart Regeneration

   • Li Wang, Jiandong Liu, Li Qian

   Pages 45-63

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6. In Vivo Cell Reprogramming to Pluripotency

   • Irene de Lázaro

   Pages 65-82

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7. In Vivo Reprogramming Towards Pluripotency for Tissue Repair and Regeneration

   • Irene de Lázaro, Kostas Kostarelos

   Pages 83-98

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8. Challenges and Future Perspectives for In Vivo Reprogramming Technology

   • Hadiseh Taheri, Cansu Gurcan, Açelya Yilmazer

   Pages 99-103

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This new volume reviews current progress on different approaches of in vivo reprogramming technology. Leaders in the field discuss how in vivo cell lineage reprogramming can be used for tissue repair and regeneration in different organs, including brain, spinal cord, pancreas, liver and heart. Recent studies on in vivo cell reprogramming towards pluripotency are reviewed; examples are given to show its potential in regenerative medicine. In each chapter, the regenerative potential of different in vivo reprogramming approaches is discussed in detail. More specifically, how different tissue failures or damages can be treated with this technology is explained. Examples from various animal models are given and the regenerative potential of in vivo reprogramming is compared to that of cell transplantation studies. The last chapter discusses current challenges of these preclinical studies and gives suggestions in order to improve the current strategies. Future directions are indicated for the transition of in vivo reprogramming technology to clinical settings. This is among the first books in the literature which specifically focuses on the in vivo reprogramming technology in regenerative medicine and these chapters collectively cover one of the most important and exciting topics of regenerative medicine.

• Brain Repair
• Cardiomyocyte Regeneration
• Cell Lineage
• Dedifferation
• Spinal Cord Injury
• Tissue Repair
• Cell culture

• Biomedical Engineering Department, Ankara University, Tandogan, Turkey

  Açelya Yilmazer

Dr. Açelya Yilmazer is as an assistant professor at the Biomedical Engineering Department and the vice director of the Stem Cell Institute of Ankara University. After receiving a BSc in Biology from the Middle East Technical University, she completed her MSc degree in Cancer Immunotherapy at the University of Nottingham and obtained her PhD in the Nanomedicine Lab based in the School of Pharmacy, University College London. She has been selected as the Best Young Investigator in Turkey by the Turkish Society of Medical Biology and Genetics. Her research laboratory focuses on cell reprogramming technologies and development of novel nanomaterial systems for directing cell fate. She is a member of the International Society of Stem Cell Research and the Biomaterials and Tissue Engineering Society of Turkey. 

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