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  • © 2015

RNA and DNA Diagnostics

  • Solves open problems in the analyses and structure of new modified bases of nucleic acids, which can be used as molecular probes in diagnosis of different diseases
  • Equips readers to handle complex issues of relation of nucleic acids structure, function and properties with human health
  • Covers many different applications of nucleic acids technologies in laboratory testing as well as clinical diagnosis of various diseases

Part of the book series: RNA Technologies (RNATECHN)

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Table of contents (16 chapters)

  1. Front Matter

    Pages i-x
  2. Electrochemical Biosensors for miRNA Detection

    • Diego Voccia, Ilaria Palchetti
    Pages 1-19
  3. Electrochemical Detection of RNA

    • Christopher Pöhlmann, Mathias Sprinzl
    Pages 21-45
  4. DNA and PNA Probes for DNA Detection in Electroanalytical Systems

    • Benoît Piro, Vincent Noël, Steeve Reisberg
    Pages 47-80
  5. DNA for Non-nucleic Acid Sensing

    • Vincent Noel, Benoit Piro, Steeve Reisberg
    Pages 81-106
  6. Aptamers in Oncotherapy

    • Darija Muharemagic, Maxim V. Berezovski
    Pages 107-121
  7. Genotyping of Single Nucleotide Polymorphisms

    • Tian Ye, Ran Tong, Zhiqiang Gao
    Pages 123-144
  8. Emergent Properties and Functions of Nanoconfined Nucleic Acid Architectures

    • Allen W. Nicholson, Shiv K. Redhu, Alex Stopar, Lucia Coral, Vincenzo Carnevale, Matteo Castronovo
    Pages 183-204
  9. RNA and DNA Diagnostics on Microspheres: Current and Emerging Methods

    • Anna Weis, Fang Liang, Jing Gao, Ross T. Barnard, Simon Corrie
    Pages 205-224
  10. Mechanochemical Sensing

    • Prakash Shrestha, Shankar Mandal, Hanbin Mao
    Pages 241-258
  11. Microarrays as Research Tools and Diagnostic Devices

    • Karin Lemuth, Steffen Rupp
    Pages 259-280
  12. Single-Molecule Strategies for DNA and RNA Diagnostics

    • D. Cibran Perez-Gonzalez, J. Carlos Penedo
    Pages 297-332
  13. Detection and Assessment of MicroRNA Expression in Human Disease

    • Adam Mitchell, Amanda Marie James, Tamas Alexy, Gang Bao, Charles D. Searles
    Pages 333-349

About this book

The aim of molecular diagnostics is preferentially to detect a developing disease before any symptoms appear. There has been a significant increase, fueled by technologies from the human genome project, in the availability of nucleic acid sequence information for all living organisms including bacteria and viruses. When combined with a different type of instrumentation applied, the resulting diagnostics is specific and sensitive. Nucleic acid-based medical diagnosis detects specific DNAs or RNAs from the infecting organism or virus and a specific gene or the expression of a gene associated with a disease. Nucleic acid approaches also stimulate a basic science by opening lines of inquiry that will lead to greater understanding of the molecules at the center of life. One can follow Richard Feynman’s famous statement “What I cannot create, I do not understand.”

Editors and Affiliations

  • Free University of Berlin Institute of Chemistry/Biochemistry, Thielallee 63, Germany

    Volker A. Erdmann

  • Nanobiomedical Center, Adam Mickiewicz University, Umultowska 85 Poznań, Poland

    Stefan Jurga

  • Institute of Bioorganic Chemistry of the Polish Academy of Sciences, Z. Noskowskiego 12/14 Poznań, Poland

    Jan Barciszewski

Bibliographic Information

  • Book Title: RNA and DNA Diagnostics

  • Editors: Volker A. Erdmann, Stefan Jurga, Jan Barciszewski

  • Series Title: RNA Technologies

  • DOI: https://doi.org/10.1007/978-3-319-17305-4

  • Publisher: Springer Cham

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer International Publishing Switzerland 2015

  • Hardcover ISBN: 978-3-319-17304-7Published: 29 June 2015

  • Softcover ISBN: 978-3-319-36199-4Published: 15 October 2016

  • eBook ISBN: 978-3-319-17305-4Published: 10 June 2015

  • Series ISSN: 2197-9731

  • Series E-ISSN: 2197-9758

  • Edition Number: 1

  • Number of Pages: X, 349

  • Number of Illustrations: 46 b/w illustrations, 78 illustrations in colour

  • Topics: Human Genetics, Nucleic Acid Chemistry, Molecular Medicine, Biotechnology

Buy it now

Buying options

eBook USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access