Handbook of Anticancer Drugs from Marine Origin

1. Front Matter

   Pages i-xvi

   PDF

2. Introduction to Anticancer Drugs from Marine Origin

   • Se-Kwon Kim, Senthilkumar Kalimuthu

   Pages 1-13

3. Triterpenoids as Anticancer Drugs from Marine Sponges

   • Yong-Xin Li, Se-Kwon Kim

   Pages 15-27

4. Marine Sponge Derived Antiangiogenic Compounds

   • Ana R. Quesada, Beatriz Martínez-Poveda, Salvador Rodríguez-Nieto, Miguel Ángel Medina

   Pages 29-58

5. Marine Sponge Derived Eribulin in Preclinical and Clinical Studies for Cancer

   • Umang Swami, Umang Shah, Sanjay Goel

   Pages 59-100

6. Antitumour Effect of Cyclodepsipeptides from Marine Sponges

   • Rosa Lemmens-Gruber

   Pages 101-111

7. Cytotoxic Cyclic Peptides from the Marine Sponges

   • Toshiyuki Wakimoto, Karen Co Tan, Hiroki Tajima, Ikuro Abe

   Pages 113-144

8. Fucoidan, A Sulfated Polysaccharides from Brown Algae as Therapeutic Target for Cancer

   • Senthilkumar Kalimuthu, Se-Kwon Kim

   Pages 145-164

9. Seaweeds-Derived Bioactive Materials for the Prevention and Treatment of Female’s Cancer

   • Ratih Pangestuti, Se-Kwon Kim

   Pages 165-176

10. Antitumor and Antimetastatic Effects of Marine Algal Polyphenols

    • Fatih Karadeniz, Se-Kwon Kim

    Pages 177-183

11. Seaweed Carotenoids for Cancer Therapeutics

    • Meganathan Boominathan, Ayyavu Mahesh

    Pages 185-203

12. Amelioration Effect of a Tertiary Sulfonium Compound, Dimethylsulfoniopropionate, in Green Sea Algae on Ehrlich Ascitic-tumor, Solid Tumor and Related Diseases

    • Kenji Nakajima

    Pages 205-238

13. The Current Status of Novel Anticancer Drugs from Marine Actinobacteria

    • Panchanathan Manivasagan, Se-Kwon Kim

    Pages 239-251

14. Natural Products with Anticancer Activity from Marine Fungi

    • Valliappan Karuppiah, Fengli Zhang, Zhiyong Li

    Pages 253-267

15. Toluquinol, A Marine Fungus Metabolite, Inhibits Some of the Hallmarks of Cancer

    • Melissa García-Caballero, Miguel Ángel Medina, Ana R. Quesada

    Pages 269-299

16. Anticancer Diketopiperazines from the Marine Fungus

    • Zhan-Lin Li, Hui-Ming Hua

    Pages 301-322

17. Meroterpenoids from Marine Microorganisms: Potential Scaffolds for New Chemotherapy Leads

    • Nelson G. M. Gomes, Suradet Buttachon, Anake Kijjoa

    Pages 323-366

18. Antitumor Compounds from Actinomycetes in Deep-sea Water of Toyama Bay

    • Yasuhiro Igarashi

    Pages 367-382

19. Tunicates: A Vertebrate Ancestral Source of Antitumor Compounds

    • Edwin L. Cooper, Ralph Albert

    Pages 383-395

20. Trabectedin (ET-743) from Marine Tunicate for Cancer Treatment

    • Harika Atmaca, Emir Bozkurt

    Pages 397-412

This timely desk reference focuses on marine-derived bioactive substances which have biological, medical and industrial applications. The medicinal value of these marine natural products are assessed and discussed. Their function as a new and important resource in novel, anticancer drug discovery research is also presented in international contributions from several research groups. For example, the potential role of Spongistatin, Apratoxin A, Eribulin mesylate, phlorotannins, fucoidan, as anticancer agents is explained. The mechanism of action of bioactive compounds present in marine algae, bacteria, fungus, sponges, seaweeds and other marine animals and plants are illustrated via several mechanisms. In addition, this handbook lists various compounds that are active candidates in chemoprevention and their target actions. The handbook also places into context the demand for anticancer nutraceuticals and their use as potential anti-cancer pharmaceuticals and medicines. This study of advanced and future types of natural compounds from marine sources is written to facilitate the understanding of Biotechnology and its application to marine natural product drug discovery research.

• Anticancer Drugs Marine Organisms
• Anticancer Drugs from Marine Sources
• Anticancer Marine Organisms
• Anticancer Seaweed
• Anticancer Sponges
• Cytotoxicity
• Cytotoxicity

• Department of Marine-Bio Convergence Science, Pukyong National University, Busan, Korea, Republic of (South Korea)

  Se-Kwon Kim

Professor Se-Kwon Kim, PhD, currently serves as a Senior Professor in the Department of Chemistry and the director of the Marine Bioprocess Research Center (MBPRC) at Pukyong National University in the Republic of Korea. He received his BSc, MSc and PhD from the Pukyong National University and joined as a faculty member. He has previously served as a scientist in the University of Illinois, Urbana Champaign, Illinois (1988-1989) and was a visiting scientist at the Memorial University of Newfoundland in Canada (1999-2000). Professor Se-Kwon Kim was president of the Korean Society of Chitin and Chitosan (1986-1990) and the Korean Society of Marine Biotechnology (2006-2007). He was also the chairman for the 7th Asia-Pacific Chitin and Chitosan Symposium, which was held in South Korea in 2006. He is one of the board members of the International Society of Marine Biotechnology and the International Society for Nutraceuticals and Functional Foods. Moreover, he was the editor in chief of the Korean Journal of Life Sciences (1995-1997), the Korean Journal of Fisheries Science and Technology (2006-2007) and the Korean Journal of Marine Bioscience and Biotechnology (2006-present). His research has been credited with the best paper award from the American Oil Chemist's Society (AOCS) and the Korean Society of Fisheries Science and Technology in 2002. Professor Se-Kwon Kim's major research interests are investigation and development of bioactive substances derived from marine organisms and their application in oriental medicine, nutraceuticals and cosmeceuticals via marine bioprocessing and mass- production technologies. He has also conducted research on the development of bioactive materials from marine organisms for applications in oriental medicine, cosmeceuticals and nutraceuticals. To date, he has authored over 500 research papers and holds 110 patents. In addition, he has written or edited more than 40 books.

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