Authors:
- Describes the progress made during more than hundred years of neuropathological HD research, the neuropathological hallmarks of HD and their pathogenic and clinical relevance
- Explains the potential pathophysiological role of axonal transport deficits and impairments of the neuronal protein quality control machinery in the disease process
- Illustrates the potential pathophysiological role of neuronal huntingtin aggregations and nerve cell alterations, as well as the possible significance of transneuronal mechanisms for the spread of the neurodegenerative process of HD
Part of the book series: Advances in Anatomy, Embryology and Cell Biology (ADVSANAT, volume 217)
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Table of contents (11 chapters)
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Front Matter
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Back Matter
About this book
Reviews
“This multiauthored monograph is a comprehensive overview of Huntington’s disease by experts in this field. … The photographs are of consistently high quality. The captions are complete and accurate. … For a basic scientist, neurologist, neuropathologist, or anyone with an interest in neurodegenerative disease, this book provides a thorough review and authoritative update on Huntington’s disease. It is a reliable resource and a complete academic delight.” (Sherry Krawitz, Doody’s Book Reviews, March, 2016)
Authors and Affiliations
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Dr. Senckenbergisches Chronomedizinisches Institut, Goethe University Frankfurt, Frankfurt, Germany
Udo Rüb
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Medical Center Neurological Institute, Columbia University, New York, USA
Jean Paul G. Vonsattel
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Division Psychiatric clinic Morphological Brain Research Unit, Julius Maximilians University Würzburg, Würzburg, Germany
Helmut Heinsen
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Dr. Senckenbergisches Chronomedizinisches Institut, Goethe-University, Frankfurt, Germany
Horst-Werner Korf
Bibliographic Information
Book Title: The Neuropathology of Huntington’s Disease: Classical Findings, Recent Developments and Correlation to Functional Neuroanatomy
Authors: Udo Rüb, Jean Paul G. Vonsattel, Helmut Heinsen, Horst-Werner Korf
Series Title: Advances in Anatomy, Embryology and Cell Biology
DOI: https://doi.org/10.1007/978-3-319-19285-7
Publisher: Springer Cham
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2015
Softcover ISBN: 978-3-319-19284-0Published: 08 October 2015
eBook ISBN: 978-3-319-19285-7Published: 29 September 2015
Series ISSN: 0301-5556
Series E-ISSN: 2192-7065
Edition Number: 1
Number of Pages: XIV, 146
Number of Illustrations: 3 b/w illustrations, 47 illustrations in colour
Topics: Neurosciences, Human Genetics, Pathology