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Synthesis and Reactivity of Donor-Acceptor Substituted Aminocyclopropanes and Aminocyclobutanes

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  • © 2016

Overview

Authors:
  1. Florian Nanteuil

    1. Inst. des sci. et ingénierie chimiques, Swiss Federal Institute of Technology in Lausanne, Lausanne, Switzerland

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  • Nominated as an outstanding PhD thesis by the EPFL, the Swiss Federal Institute of Technology in Lausanne, Switzerland
  • Establishes the first use of aminocyclopropanes and aminocyclobutanes as formal dipoles in annulation reactions
  • Allows the unprecedented enantioselective formation of Aminocyclopentanes and Aminotetrahydrofurans by means of a dynamic-kinetic asymmetric transformation
  • Includes supplementary material: sn.pub/extras

Part of the book series: Springer Theses (Springer Theses)

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Table of contents (5 chapters)

  1. Front Matter

    Pages i-xvii
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  2. Introduction

    • Florian de Nanteuil
    Pages 1-60

  3. Ring-Opening Reactions of Aminocyclopropanes

    • Florian de Nanteuil
    Pages 61-125

  4. Synthesis and [4 + 2] Annulation of Aminocyclobutanes

    • Florian de Nanteuil
    Pages 127-146

  5. Conclusions and Outlook

    • Florian de Nanteuil
    Pages 147-151

  6. Experimental Part

    • Florian de Nanteuil
    Pages 153-315
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Keywords

About this book

This thesis presents a general approach to accessing nitrogen-substituted hetero- and carbocycles. In short, the annulation reactions developed in the thesis make it possible to access nitrogen-substituted four-, five- and six-membered rings, all essential building blocks for the synthesis of bioactive molecules. Many natural products display a saturated polycyclic core allowing a well-defined arrangement of functional groups in space. As such, they can interact with biological targets with a high degree of affinity and selectivity, surpassing many synthetic drugs. Nevertheless, the efficient synthesis of such complex ring systems poses a challenge for organic chemistry. Through careful tuning of the electronic properties of a nitrogen donor group and a diester acceptor group, the first [3+2] annulation reaction between aminocyclopropanes and enol ethers or carbonyl compounds is now possible. The reaction proceeded under mild catalytic conditions, and the building blocks obtained can be found at the core of bioactive alkaloids, drugs such as Ramipril and biomolecules such as DNA and RNA. Thanks to the dynamic kinetic asymmetric annulation of aminocyclopropanes with enol ethers and aldehydes, access to enantioenriched compounds is also now possible. Lastly, a synthesis of donor-acceptor aminocyclobutanes via [2+2] cycloaddition using a cheap iron catalyst was developed, allowing them to be used in [4+2] annulations to access cyclohexylamines.

Authors and Affiliations

  • Inst. des sci. et ingĂ©nierie chimiques, Swiss Federal Institute of Technology in Lausanne, Lausanne, Switzerland

    Florian Nanteuil

Bibliographic Information

  • Book Title: Synthesis and Reactivity of Donor-Acceptor Substituted Aminocyclopropanes and Aminocyclobutanes

  • Authors: Florian Nanteuil

  • Series Title: Springer Theses

  • DOI: https://doi.org/10.1007/978-3-319-23006-1

  • Publisher: Springer Cham

  • eBook Packages: Chemistry and Materials Science, Chemistry and Material Science (R0)

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2016

  • Hardcover ISBN: 978-3-319-23005-4Published: 05 October 2015

  • Softcover ISBN: 978-3-319-37036-1Published: 23 August 2016

  • eBook ISBN: 978-3-319-23006-1Published: 26 September 2015

  • Series ISSN: 2190-5053

  • Series E-ISSN: 2190-5061

  • Edition Number: 1

  • Number of Pages: XVII, 315

  • Topics: Bioorganic Chemistry, Medicinal Chemistry, Carbohydrate Chemistry

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