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Systems Biology

  • Book
  • © 2018

Overview

Editors:
  1. Nikolaus Rajewsky

    1. Max Delbrück Center for Molecular Medicine, Berlin Institute for Medical Systems Biology, Berlin-Buch, Germany

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  2. Stefan Jurga

    1. Nanobiomedical Center, Adam Mickiewicz University, Poznań, Poland

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    You can also search for this editor in PubMed   Google Scholar

  3. Jan Barciszewski

    1. Polish Academy of Sciences, Institute of Bioorganic Chemistry, Poznań, Poland

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    You can also search for this editor in PubMed   Google Scholar

  • Presents a wide spectrum of topics from fundamentals of modelling networks, to image-driven systems biology and personalized medicine
  • Combines fundamentals with clinical and agricultural applications
  • With a special topic on epigenetics in agriculture

Part of the book series: RNA Technologies (RNATECHN)

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Table of contents (19 chapters)

  1. Front Matter

    Pages i-x
    Download chapter PDF

  2. Systems Biology of Genome Structure and Dynamics

    • Zahra Fahmi, Sven A. Sewitz, Karen Lipkow
    Pages 1-15

  3. A Systems Perspective of Complex Diseases: From Reductionism to Integration

    • Khushdeep Bandesh, Pawan K. Dhar, Dwaipayan Bharadwaj
    Pages 17-36

  4. Systems Biology of Bacterial Immune Systems: Regulation of Restriction-Modification and CRISPR-Cas Systems

    • Andjela Rodic, Bojana Blagojevic, Marko Djordjevic
    Pages 37-58

  5. Systems Biology of RNA-Binding Proteins in Amyotrophic Lateral Sclerosis

    • Tara Kashav, Vijay Kumar
    Pages 59-75

  6. Systems Approaches to Map In Vivo RNA–Protein Interactions in Arabidopsis thaliana

    • Martin Lewinski, Tino Köster
    Pages 77-95

  7. Systems-Level Analysis of Bacterial Regulatory Small RNA Networks

    • Julia Wong, Ignatius Pang, Marc Wilkins, Jai J. Tree
    Pages 97-127

  8. Epioncogene Networks: Identification of Epigenomic and Transcriptomic Cooperation by Multi-omics Integration of ChIP-Seq and RNA-Seq Data

    • Fabian Volker Filipp
    Pages 129-151

  9. Coupling Large-Scale Omics Data for Deciphering Systems Complexity

    • Ali Nehme, Zahraa Awada, Firas Kobeissy, Frédéric Mazurier, Kazem Zibara
    Pages 153-172

  10. Deciphering the Universe of RNA Structures and trans RNA–RNA Interactions of Transcriptomes In Vivo: From Experimental Protocols to Computational Analyses

    • Stefan R. Stefanov, Irmtraud M. Meyer
    Pages 173-216Open Access

  11. Is Autogenous Posttranscriptional Gene Regulation Common?

    • Gary D. Stormo
    Pages 217-227

  12. The Interplay of Non-coding RNAs and X Chromosome Inactivation in Human Disease

    • Francesco Russo, Federico De Masi, Søren Brunak, Kirstine Belling
    Pages 229-238

  13. Novel Insights of the Gene Translational Dynamic and Complex Revealed by Ribosome Profiling

    • Zhe Wang, Zhenglong Gu
    Pages 239-256

  14. Biophysical Analysis of miRNA-Dependent Gene Regulation

    • Andrea Riba, Matteo Osella, Michele Caselle, Mihaela Zavolan
    Pages 257-273

  15. Modeling and Analyzing the Flow of Molecular Machines in Gene Expression

    • Yoram Zarai, Michael Margaliot, Tamir Tuller
    Pages 275-300

  16. Robust Approaches to Generating Reliable Predictive Models in Systems Biology

    • Kiri Choi
    Pages 301-312

  17. Hints from Information Theory for Analyzing Dynamic and High-Dimensional Biological Data

    • Kumar Selvarajoo, Vincent Piras, Alessandro Giuliani
    Pages 313-336

  18. Enhancing Metabolic Models with Genome-Scale Experimental Data

    • Kristian Jensen, Steinn Gudmundsson, Markus J. Herrgård
    Pages 337-350

  19. An Integrative MuSiCO Algorithm: From the Patient-Specific Transcriptional Profiles to Novel Checkpoints in Disease Pathobiology

    • Anastasia Meshcheryakova, Philip Zimmermann, Rupert Ecker, Felicitas Mungenast, Georg Heinze, Diana Mechtcheriakova
    Pages 351-372

  20. Nanocellulose: A New Multifunctional Tool for RNA Systems Biology Research

    • Elena Bencurova, Meik Kunz, Thomas Dandekar
    Pages 373-401
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Keywords

About this book

Many breakthroughs in experimental devices, advanced software, as well as analytical methods for systems biology development have helped shape the way we study DNA, RNA and proteins, on the genomic, transcriptional, translational and posttranslational level. This book highlights the comprehensive topics that encompass systems biology with enormous progress in the development of genome sequencing, proteomic and metabolomic methods in designing and understanding biological systems.

Topics covered in this book include fundamentals of modelling networks, circuits and pathways, spatial and multi cellular systems, image-driven systems biology, evolution, noise and decision-making in single cells, systems biology of disease and immunology, and personalized medicine. Special attention is paid to epigenomics, in particular environmental conditions that impact genetic background. The breadth of exciting new data towards discovering fundamental principles and direct applicationof epigenetics in agriculture is also described.

The chapter “Deciphering the Universe of RNA Structures and Trans RNA-RNA Interactions of Transcriptomes in vivo - from Experimental Protocols to Computational Analyses” is available open access under a CC BY 4.0 license via link.springer.com.


Editors and Affiliations

  • Max Delbrück Center for Molecular Medicine, Berlin Institute for Medical Systems Biology, Berlin-Buch, Germany

    Nikolaus Rajewsky

  • Nanobiomedical Center, Adam Mickiewicz University, Poznań, Poland

    Stefan Jurga

  • Polish Academy of Sciences, Institute of Bioorganic Chemistry, Poznań, Poland

    Jan Barciszewski

About the editors

​Prof. Dr. Nikolaus Rajewsky,
Berlin Inst. for Medical Systems Biology, 
MaxDelbrückCenter for Molecular Medicine,
Berlin-Buch,
Germany
rajewsky@mdc-berlin.de


Prof. Dr. Stefan Jurga, 
Adam Mickiewicz University, 
Nanobiomedical Center,
Poznań,
Poland
stjurga@amu.edu.pl


Prof. Dr. Jan Barciszewski, 
Polish Academy of Sciences,
Institute of Bioorganic Chemistry,
Poznań,
Poland
jan.barciszewski@ibch.poznan.pl

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