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Impact of Survivin Acetylation on its Biological Function

  • Book
  • © 2017

Overview

Authors:
  1. David Dannheisig

    1. Ulm, Germany

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  • Study on the Biological Function of Survivin
  • Includes supplementary material: sn.pub/extras

Part of the book series: BestMasters (BEST)

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Table of contents (5 chapters)

  1. Front Matter

    Pages I-XXIII
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  2. Introduction

    • David Dannheisig
    Pages 1-28

  3. Material

    • David Dannheisig
    Pages 29-41

  4. Methods

    • David Dannheisig
    Pages 43-63

  5. Results

    • David Dannheisig
    Pages 65-79

  6. Discussion

    • David Dannheisig
    Pages 81-90

  7. Back Matter

    Pages 91-104
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Keywords

About this book

In his research, David Dannheisig investigates the influence of lysine129 acetylation on the biological function of survivin including alteration of nucleocytoplasmic shuttling as well as dimerization behavior. Since survivin participates in two major hallmarks of oncogenesis, namely cell death inhibition and chromosomal segregation during the cell cycle, it reflects a valuable target in cancer therapy and research. The author establishes proximity-dependent, fluorescence-microscopic methods to quantify the interaction of survivin with the export receptor Crm1 as well as the homodimerization itself. In the future, those systems can be usedto examine the feasible effect of chemical modulators which are targeting these interactions in a cellular background. The outcome achieved is an essential step towards the enhancement of potential cancer therapies.

Authors and Affiliations

  • Ulm, Germany

    David Dannheisig

About the author

David Dannheisig currently is a student of the International Graduate School in Molecular Medicine (IGradU) pursuing his PhD (Dr. rer. nat) degree at the Institute of Biochemistry and Molecular Biology (iBMB) at Ulm University, Germany.

Bibliographic Information

  • Book Title: Impact of Survivin Acetylation on its Biological Function

  • Authors: David Dannheisig

  • Series Title: BestMasters

  • DOI: https://doi.org/10.1007/978-3-658-18623-4

  • Publisher: Springer Spektrum Wiesbaden

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Fachmedien Wiesbaden GmbH, part of Springer Nature 2017

  • Softcover ISBN: 978-3-658-18622-7Published: 16 June 2017

  • eBook ISBN: 978-3-658-18623-4Published: 06 June 2017

  • Series ISSN: 2625-3577

  • Series E-ISSN: 2625-3615

  • Edition Number: 1

  • Number of Pages: XXIII, 104

  • Number of Illustrations: 31 b/w illustrations, 10 illustrations in colour

  • Topics: Cancer Research, Biomedical Engineering/Biotechnology, Cell Biology

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