Skip to main content
  • Book
  • © 2018

Systems Biology

  • Presents a wide spectrum of topics from fundamentals of modelling networks, to image-driven systems biology and personalized medicine
  • Combines fundamentals with clinical and agricultural applications
  • With a special topic on epigenetics in agriculture

Part of the book series: RNA Technologies (RNATECHN)

Buy it now

Buying options

eBook USD 139.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 179.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 179.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access

This is a preview of subscription content, log in via an institution to check for access.

Table of contents (19 chapters)

  1. Front Matter

    Pages i-x
  2. Systems Biology of Genome Structure and Dynamics

    • Zahra Fahmi, Sven A. Sewitz, Karen Lipkow
    Pages 1-15
  3. A Systems Perspective of Complex Diseases: From Reductionism to Integration

    • Khushdeep Bandesh, Pawan K. Dhar, Dwaipayan Bharadwaj
    Pages 17-36
  4. Systems-Level Analysis of Bacterial Regulatory Small RNA Networks

    • Julia Wong, Ignatius Pang, Marc Wilkins, Jai J. Tree
    Pages 97-127
  5. Coupling Large-Scale Omics Data for Deciphering Systems Complexity

    • Ali Nehme, Zahraa Awada, Firas Kobeissy, Frédéric Mazurier, Kazem Zibara
    Pages 153-172
  6. The Interplay of Non-coding RNAs and X Chromosome Inactivation in Human Disease

    • Francesco Russo, Federico De Masi, Søren Brunak, Kirstine Belling
    Pages 229-238
  7. Biophysical Analysis of miRNA-Dependent Gene Regulation

    • Andrea Riba, Matteo Osella, Michele Caselle, Mihaela Zavolan
    Pages 257-273
  8. Modeling and Analyzing the Flow of Molecular Machines in Gene Expression

    • Yoram Zarai, Michael Margaliot, Tamir Tuller
    Pages 275-300
  9. Hints from Information Theory for Analyzing Dynamic and High-Dimensional Biological Data

    • Kumar Selvarajoo, Vincent Piras, Alessandro Giuliani
    Pages 313-336
  10. Enhancing Metabolic Models with Genome-Scale Experimental Data

    • Kristian Jensen, Steinn Gudmundsson, Markus J. Herrgård
    Pages 337-350
  11. An Integrative MuSiCO Algorithm: From the Patient-Specific Transcriptional Profiles to Novel Checkpoints in Disease Pathobiology

    • Anastasia Meshcheryakova, Philip Zimmermann, Rupert Ecker, Felicitas Mungenast, Georg Heinze, Diana Mechtcheriakova
    Pages 351-372
  12. Nanocellulose: A New Multifunctional Tool for RNA Systems Biology Research

    • Elena Bencurova, Meik Kunz, Thomas Dandekar
    Pages 373-401

About this book

Many breakthroughs in experimental devices, advanced software, as well as analytical methods for systems biology development have helped shape the way we study DNA, RNA and proteins, on the genomic, transcriptional, translational and posttranslational level. This book highlights the comprehensive topics that encompass systems biology with enormous progress in the development of genome sequencing, proteomic and metabolomic methods in designing and understanding biological systems.

Topics covered in this book include fundamentals of modelling networks, circuits and pathways, spatial and multi cellular systems, image-driven systems biology, evolution, noise and decision-making in single cells, systems biology of disease and immunology, and personalized medicine. Special attention is paid to epigenomics, in particular environmental conditions that impact genetic background. The breadth of exciting new data towards discovering fundamental principles and direct applicationof epigenetics in agriculture is also described.

The chapter “Deciphering the Universe of RNA Structures and Trans RNA-RNA Interactions of Transcriptomes in vivo - from Experimental Protocols to Computational Analyses” is available open access under a CC BY 4.0 license via link.springer.com.


Editors and Affiliations

  • Max Delbrück Center for Molecular Medicine, Berlin Institute for Medical Systems Biology, Berlin-Buch, Germany

    Nikolaus Rajewsky

  • Nanobiomedical Center, Adam Mickiewicz University, Poznań, Poland

    Stefan Jurga

  • Polish Academy of Sciences, Institute of Bioorganic Chemistry, Poznań, Poland

    Jan Barciszewski

About the editors

​Prof. Dr. Nikolaus Rajewsky,
Berlin Inst. for Medical Systems Biology, 
MaxDelbrückCenter for Molecular Medicine,
Berlin-Buch,
Germany
rajewsky@mdc-berlin.de


Prof. Dr. Stefan Jurga, 
Adam Mickiewicz University, 
Nanobiomedical Center,
Poznań,
Poland
stjurga@amu.edu.pl


Prof. Dr. Jan Barciszewski, 
Polish Academy of Sciences,
Institute of Bioorganic Chemistry,
Poznań,
Poland
jan.barciszewski@ibch.poznan.pl

Bibliographic Information

Buy it now

Buying options

eBook USD 139.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 179.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 179.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access