Metabolic Engineering for Bioactive Compounds

This book comprehensively discusses the latest research in the area of metabolic engineering. Metabolic engineering solutions for bioactive compounds are now being derived by means of heterologous gene expression, in a wide range of organisms. The book provides an overview of the model systems being employed for metabolic manipulation to yield bioactive molecules, such as single-cell proteins, antibody generation, metabolites, proteases, chaperones, therapeutic proteins, nanomaterials, polymeric conjugates, dendrimers and nanoassemblies, Escherichia coli, Agrobacterium, Saccharomyces cerevisiae and cell lines, etc. In addition, it shares insights into the scope of these methods in the areas of prevention, diagnosis and treatment of diseases, e.g. immunotherapy for curing various diseases like cancer, allergies, autoimmune diseases, etc.

• gene expression
• nanoparticles
• genome engineering
• metabolomics
• fermentation

• Microbial Biotechnology and Genomics, CSIR - Institute of Genomics and Integrative Biology (IGIB), New Delhi, India

  Vipin Chandra Kalia

• Faculty of Applied Sciences and Biotechnology, Shoolini University of Biotechnology and Management Sciences, Solan, India

  Adesh Kumar Saini

Dr. Vipin Chandra Kalia is an Emeritus Scientist of the CSIR Institute of Genomics and Integrative Biology, Delhi. He holds an M.Sc. and Ph.D. in Genetics, both from the Indian Agricultural Research Institute, New Delhi. Further, he is a Fellow of the National Academy of Sciences, National Academy of Agricultural Sciences, and Association of Microbiologists of India. 

His main areas of research are microbial biodiversity, bioenergy, biopolymers, quorum sensing and quenching, and drug discovery. He has published more than 100 papers in scientific journals including Nature Biotechnology, Biotechnology Advances, and Bioresource Technology. 

He has authored 14 book chapters. He has edited seven books and is currently the Editor-in-Chief of the Indian Journal of Microbiology (since 2013) and Editor of several journals, including the Journal of Microbiology & Biotechnology (Korea) and Dataset Papers in Microbiology. He is a member of numerous professional associations, including the Society of Biological Chemists of India and the Biotech Research Society of India (BRSI). He can be contacted at: vckalia@igib.res.in; vc_kalia@yahoo.co.in

Dr. Adesh Kumar Saini is a Professor and Director of the Center of Research for Himalayan Sustainability and Development, Shoolini University, India. He received his Ph.D. in Microbiology from the CSIR Institute of Genomics and Integrative Biology and completed his post-doctoral research at the National Institutes of Health. His main areas of research are microbial biodiversity, sustainable development of the Himalayan ecosystem, and yeast cell biology. He has published more than 25 papers in prominent scientific journals, including the EMBO Journal and Journal of Biological Chemistry. His research projects aim at plant-growth-promoting rhizobacteria (PGPR), and post-fire management in the pine forests and revival of forest productivity. He can be contacted at: sainiade@gmail.com; adeshsaini@shooliniuniversity.com

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