Optimization of Behavioral, Biobehavioral, and Biomedical Interventions

1. Front Matter

   Pages i-xxxi

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2. Conceptual Introduction to the Multiphase Optimization Strategy (MOST)

   • Linda M. Collins

   Pages 1-34

3. The Preparation Phase of MOST

   • Linda M. Collins

   Pages 35-65

4. Introduction to the Factorial Optimization Trial

   • Linda M. Collins

   Pages 67-113

5. Interactions Between Components and Moderation of Component Effects

   • Linda M. Collins

   Pages 115-143

6. Balanced and Unbalanced Reduced Factorial Designs

   • Linda M. Collins

   Pages 145-191

7. Gathering Information for Decision-Making in the Optimization Phase: Resource Management and Practical Issues

   • Linda M. Collins

   Pages 193-225

8. The Completion of the Optimization Phase

   • Linda M. Collins

   Pages 227-266

9. Introduction to Adaptive Interventions

   • Linda M. Collins

   Pages 267-287

10. Back Matter

    Pages 289-297

    PDF

This book presents a framework for development, optimization, and evaluation of behavioral,  biobehavioral, and biomedical interventions.  Behavioral, biobehavioral, and biomedical interventions are programs with the objective of improving and maintaining human health and well-being, broadly defined, in individuals, families, schools, organizations, or communities.  These interventions may be aimed at, for example, preventing or treating disease, promoting physical and mental health, preventing violence, or improving academic achievement.  

This volume introduces the multiphase optimization strategy (MOST), pioneered at The Methodology Center at the Pennsylvania State University, as an alternative to the classical approach of relying solely on the randomized controlled trial (RCT).  MOST borrows heavily from perspectives taken and approaches used in engineering, and also integrates concepts from statistics and behavioral science, including the RCT.  As described in detail in this book, MOST consists of three phases: preparation, in which the conceptual model underlying the intervention is articulated; optimization, in which experimentation is used to gather the information necessary to identify the optimized intervention; and evaluation, in which the optimized intervention is evaluated in a standard RCT.  Through numerous examples, the book demonstrates that MOST can be used to develop interventions that are more effective, efficient, economical, and scalable.

Optimization of Behavioral, Biobehavioral, and Biomedical Interventions: The Multiphase Optimization Strategy is the first book to present a comprehensive introduction to MOST. It will be an essential resource for behavioral, biobehavioral, and biomedical scientists; statisticians, biostatisticians, and analysts working in epidemiology and public health; and graduate-level courses in development and evaluation of interventions.

• Behavioral Intervention
• Experimental design
• Factorial experiment
• Fractional factorial experiment
• MOST
• Multiphase optimization strategy
• Optimized behavioral interventions

• The Methodology Center, The Pennsylvania State University, University Park, USA

  Linda M. Collins

Linda M. Collins is Distinguished Professor of Human Development and Family Studies, Professor of Statistics, and the director of The Methodology Center at the Pennsylvania State University. She is interested in most aspects of research methods.  Her current work focuses on experimental and non-experimental design, particularly for building, optimizing, and evaluating behavioral, biobehavioral, and biomedical interventions. Professor Collins also has a long-standing interest in models for longitudinal data, particularly latent transition analysis, and other latent class models.    

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