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Advances in Heart Valve Biomechanics

Valvular Physiology, Mechanobiology, and Bioengineering

  • Book
  • © 2018

Overview

Editors:
  1. Michael S. Sacks

    1. The Oden Institute and the Department of Biomedical Engineering, The University of Texas at Austin, Austin, USA

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    You can also search for this editor in PubMed   Google Scholar

  2. Jun Liao

    1. The Department of Bioengineering, The University of Texas at Arlington, Arlington, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • Covers the latest research accomplishments in heart valve biomechanics

  • Broadens readers’ understanding of novel concepts in valvular tissue viscoelasticity, collagen fibril/molecule mechanisms, hierarchical response of valvular tissue under deformation, cell-ECM interaction, and integrative multi-scale models

  • Maximizes reader insights into advanced computational modeling and simulation efforts of heart valve biomechanics driven by updated knowledge and high performance computing

  • Reviews exhaustively the key recent research into biomechanical investigations on the breakthrough approach/techniques such as tissue engineered heart valve/regeneration, transcatheter valve replacement, 3D imaging guided valve repair, and 3D bioprinting

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Table of contents (18 chapters)

  1. Front Matter

    Pages i-xxv
    Download chapter PDF

  2. Native Heart Valve Function

    1. Front Matter

      Pages 1-1
      Download chapter PDF

    2. Biological Mechanics of the Heart Valve Interstitial Cell

      • Alex Khang, Rachel M. Buchanan, Salma Ayoub, Bruno V. Rego, Chung-Hao Lee, Michael S. Sacks
      Pages 3-36

    3. Endothelial Mechanotransduction

      • James N. Warnock
      Pages 37-58

    4. The Role of Proteoglycans and Glycosaminoglycans in Heart Valve Biomechanics

      • Varun K. Krishnamurthy, K. Jane Grande-Allen
      Pages 59-79

    5. On the Unique Functional Elasticity and Collagen Fiber Kinematics of Heart Valve Leaflets

      • Jun Liao, Michael S. Sacks
      Pages 81-104

    6. Tricuspid Valve Biomechanics: A Brief Review

      • William D. Meador, Mrudang Mathur, Manuel K. Rausch
      Pages 105-114

    7. Measurement Technologies for Heart Valve Function

      • Morten O. Jensen, Andrew W. Siefert, Ikechukwu Okafor, Ajit P. Yoganathan
      Pages 115-149

  3. Heart Valve Disease and Treatment

    1. Front Matter

      Pages 151-151
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    2. Calcific Aortic Valve Disease: Pathobiology, Basic Mechanisms, and Clinical Strategies

      • Payal Vyas, Joshua D. Hutcheson, Elena Aikawa
      Pages 153-179

    3. Remodelling Potential of the Mitral Heart Valve Leaflet

      • Bruno V. Rego, Sarah M. Wells, Chung-Hao Lee, Michael S. Sacks
      Pages 181-206

    4. Molecular and Cellular Developments in Heart Valve Development and Disease

      • Lindsey J. Anstine, Anthony S. Baker, Joy Lincoln
      Pages 207-239

    5. Mechanical Mediation of Signaling Pathways in Heart Valve Development and Disease

      • Ishita Tandon, Ngoc Thien Lam, Kartik Balachandran
      Pages 241-262

    6. Tissue Engineered Heart Valves

      • Jay M. Reimer, Robert T. Tranquillo
      Pages 263-288

    7. Decellularization in Heart Valve Tissue Engineering

      • Katherine M. Copeland, Bo Wang, Xiaodan Shi, Dan T. Simionescu, Yi Hong, Pietro Bajona et al.
      Pages 289-317

    8. Novel Bioreactors for Mechanistic Studies of Engineered Heart Valves

      • Kristin Comella, Sharan Ramaswamy
      Pages 319-335

    9. Bioprosthetic Heart Valves: From a Biomaterials Perspective

      • Naren Vyavahare, Hobey Tam
      Pages 337-382

  4. Computational Approaches for Heart Valve Function

    1. Front Matter

      Pages 383-383
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    2. Computational Modeling of Heart Valves: Understanding and Predicting Disease

      • Ahmed A. Bakhaty, Ali Madani, Mohammad R. K. Mofrad
      Pages 385-411

    3. Biomechanics and Modeling of Tissue-Engineered Heart Valves

      • T. Ristori, A. J. van Kelle, F. P. T. Baaijens, S. Loerakker
      Pages 413-446
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Keywords

About this book

This book covers the latest research development in heart valve biomechanics and bioengineering, with an emphasis on novel experimentation, computational simulation, and applications in heart valve bioengineering. The most current research accomplishments are covered in detail, including novel concepts in valvular viscoelasticity, fibril/molecular mechanisms of tissue behavior, fibril kinematics-based constitutive models, mechano-interaction of valvular interstitial and endothelial cells, biomechanical behavior of acellular valves and tissue engineered valves, novel bioreactor designs, biomechanics of transcatheter valves, and 3D heart valve printing. This is an ideal book for biomedical engineers, biomechanics, surgeons, clinicians, business managers in the biomedical industry, graduate and undergraduate students studying biomedical engineering, and medical students. 

Editors and Affiliations

  • The Oden Institute and the Department of Biomedical Engineering, The University of Texas at Austin, Austin, USA

    Michael S. Sacks

  • The Department of Bioengineering, The University of Texas at Arlington, Arlington, USA

    Jun Liao

About the editors

Dr. Michael Sacks is a Professor of Biomedical Engineering at The University of Texas at Austin. He is a world authority on cardiovascular biomechanics, particularly on the biomechanical behavior and function of heart valves and developing patient-specific simulation-based approaches for the treatment of valve diseases. His research is based on rigorous quantification, mathematical modeling, and simulation of the mechanical behavior of the cells and tissues of the cardiovascular system in health and disease. His approaches include multi-scale studies of cell/tissue/organ, especially how they mechanical interact as a system. Dr. Sacks is also active in the biomechanics of engineered tissues and scaffolds and in understanding the in-vitro and in-vivo remodeling processes from a functional biomechanical perspective.


Dr. Jun Liao is an Associate Professor of Biomedical Engineering at the University of Texas at Arlington. Dr. Liao is an expert in tissue biomechanics and bioengineering, with interests in heart valves, cardiac muscle, and many other soft tissues. His research focus is to better understand the role of biomechanics in maintaining optimal tissue performance in physiological conditions and the biomechanical abnormality in diseased conditions, aiming to improving tissue replacement, repair, and medical intervention for diseases. Dr. Liao is a member of BMES, ASME, and AAAS and a Fellow of the American Heart Association. 




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