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Monooxygenase, Peroxidase and Peroxygenase Properties and Mechanisms of Cytochrome P450

  • Book
  • © 2015

Overview

Editors:
  1. Eugene G. Hrycay

    1. Faculty of Pharmaceutical Sciences, The University of British Columbia, Vancouver, Canada

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    You can also search for this editor in PubMed   Google Scholar

  2. Stelvio M. Bandiera

    1. Fac. of Pharmaceutical Sciences, The University of British Columbia , Vancouver, Canada

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • This is the first book that provides up-to-date, comprehensive reviews on the monooxygenase, peroxidase and peroxygenase properties and mechanisms of cytochrome P450 enzymes in 13 chapters compiled by leading scientists in their field
  • This book is available in paper and electronic formats and will be helpful to researchers and graduate students in their areas
  • Customers should purchase this book as there are no recent books on the market that review the peroxidase and peroxygenase properties of cytochrome P450 enzymes
  • Includes supplementary material: sn.pub/extras

Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 851)

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Table of contents (13 chapters)

  1. Front Matter

    Pages i-xv
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  2. Monooxygenase, Peroxidase and Peroxygenase Properties and Reaction Mechanisms of Cytochrome P450 Enzymes

    • Eugene G. Hrycay, Stelvio M. Bandiera
    Pages 1-61

  3. Oxidizing Intermediates in P450 Catalysis: A Case for Multiple Oxidants

    • Anuja R. Modi, John H. Dawson
    Pages 63-81

  4. Current Approaches for Investigating and Predicting Cytochrome P450 3A4-Ligand Interactions

    • Irina F. Sevrioukova, Thomas L. Poulos
    Pages 83-105

  5. Acyl-Carbon Bond Cleaving Cytochrome P450 Enzymes: CYP17A1, CYP19A1 and CYP51A1

    • Muhammad Akhtar, J. Neville Wright
    Pages 107-130

  6. Regioselective Versatility of Monooxygenase Reactions Catalyzed by CYP2B6 and CYP3A4: Examples with Single Substrates

    • Claudio A. Erratico, Anand K. Deo, Stelvio M. Bandiera
    Pages 131-149

  7. Cytochrome P450 Enzymes in the Bioactivation of Polyunsaturated Fatty Acids and Their Role in Cardiovascular Disease

    • Christina Westphal, Anne Konkel, Wolf-Hagen Schunck
    Pages 151-187

  8. Monooxygenation of Small Hydrocarbons Catalyzed by Bacterial Cytochrome P450s

    • Osami Shoji, Yoshihito Watanabe
    Pages 189-208

  9. Use of Chemical Auxiliaries to Control P450 Enzymes for Predictable Oxidations at Unactivated C-H Bonds of Substrates

    • Karine Auclair, Vanja Polic
    Pages 209-228

  10. Cytochrome P450 Enzymes and Electrochemistry: Crosstalk with Electrodes as Redox Partners and Electron Sources

    • Victoria V. Shumyantseva, Tatiana Bulko, Evgeniya Shich, Anna Makhova, Alexey Kuzikov, Alexander Archakov
    Pages 229-246

  11. Mechanistic Basis of Electron Transfer to Cytochromes P450 by Natural Redox Partners and Artificial Donor Constructs

    • Peter Hlavica
    Pages 247-297

  12. Biological Diversity of Cytochrome P450 Redox Partner Systems

    • Kirsty J. McLean, Dominika Luciakova, James Belcher, Kang Lan Tee, Andrew W. Munro
    Pages 299-317

  13. Cytochrome P450cin (CYP176A1)

    • Jeanette E. Stok, Kate E. Slessor, Anthony J. Farlow, David B. Hawkes, James J. De Voss
    Pages 319-339

  14. Fungal Unspecific Peroxygenases: Heme-Thiolate Proteins That Combine Peroxidase and Cytochrome P450 Properties

    • Martin Hofrichter, Harald Kellner, Marek J. Pecyna, René Ullrich
    Pages 341-368
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Keywords

About this book

This book describes in 13 chapters mechanisms of P450 used to monooxygenate substrates via the NAD(P)H/O2 pathway using its peroxidase and peroxygenase functions. P450 also utilizes peroxides, peracids, periodate and iodosobenzene to oxygenate substrates via the shunt pathway. Also described are mechanisms used in the oxidation of pharmaceuticals by CYP3A4; acyl- carbon cleavage by CYP17A1, CYP19A1 and CYP51A1; metabolism of tetrabromodiphenyl ethers and bile acids by CYP2B6 and CYP3A4; metabolism of ω-6 and ω-3 polyunsaturated fatty acids; H2O2-mediated peroxygenation of substrates using substrate misrecognition; P450 oxidative reactions using electrochemical methods; electron transfer to P450 by redox proteins; hydroxylation of 1,8-cineole by P450cin; and peroxygenation by unspecific peroxygenases using H2O2. The topics covered are relevant to P450 researchers, professors and students from a variety of disciplines ranging from pharmacology, toxicology and microbiology to chemistry.

Editors and Affiliations

  • Faculty of Pharmaceutical Sciences, The University of British Columbia, Vancouver, Canada

    Eugene G. Hrycay

  • Fac. of Pharmaceutical Sciences, The University of British Columbia , Vancouver, Canada

    Stelvio M. Bandiera

Bibliographic Information

  • Book Title: Monooxygenase, Peroxidase and Peroxygenase Properties and Mechanisms of Cytochrome P450

  • Editors: Eugene G. Hrycay, Stelvio M. Bandiera

  • Series Title: Advances in Experimental Medicine and Biology

  • DOI: https://doi.org/10.1007/978-3-319-16009-2

  • Publisher: Springer Cham

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2015

  • Hardcover ISBN: 978-3-319-16008-5Published: 09 June 2015

  • Softcover ISBN: 978-3-319-34794-3Published: 12 October 2016

  • eBook ISBN: 978-3-319-16009-2Published: 22 May 2015

  • Series ISSN: 0065-2598

  • Series E-ISSN: 2214-8019

  • Edition Number: 1

  • Number of Pages: XV, 368

  • Number of Illustrations: 91 b/w illustrations, 59 illustrations in colour

  • Topics: Biomedicine general

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