Artemisia annua - Pharmacology and Biotechnology

1. Front Matter

   Pages i-vi

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2. How Techniques of Herbal Drug Preparation Affect the Therapeutic Outcome: Reflections on Qinghao 青蒿 (Herba Artemisiae annuae) in the History of the Chinese Materia Medica

   • Elisabeth Hsu

   Pages 1-7

3. Ethnopharmacology of Artemisia annua L.: A Review

   • Alia Sadiq, Muhammad Qasim Hayat, Muhammad Ashraf

   Pages 9-25

4. Artemisia annua: A Miraculous Herb to Cure Malaria

   • M. Naeem, Mohd Idrees, Minu Singh, M. Masroor A. Khan, Moinuddin

   Pages 27-49

5. Whole Plant Approaches to Therapeutic Use of Artemisia annua L. (Asteraceae)

   • Pamela Weathers, Kirsten Reed, Ahmed Hassanali, Pierre Lutgen, Patrick Ogwang Engeu

   Pages 51-74

6. Pharmacological Potentials of Artemisinin and Related Sesquiterpene Lactones: Recent Advances and Trends

   • María José Abad Martínez, Luis Miguel Bedoya del Olmo, Luis Apaza Ticona, Paulina Bermejo Benito

   Pages 75-93

7. Taxonomic Implications of Artemisia annua L.

   • Sadia Malik, Muhammad Qasim Hayat, Muhammad Ashraf

   Pages 95-112

8. Trichomes in Artemisia annua: Initiation, Development, Maturation and the Possibilities to Influence these Factors

   • Anders Kjaer, Kai Grevsen, Martin Jensen

   Pages 113-123

9. Potential Methods to Improve the Efficiency of Artemisinin Extraction from Artemisia annua

   • Rhianna Briars, Larysa Paniwnyk

   Pages 125-137

10. Extraction, Purification, and Quantification of Artemisinin and its Analogs from Artemisia annua L.

    • Shuoqian Liu, Na Tian, Zhonghua Liu

    Pages 139-155

11. Effect of Mineral Nutrition, Growth Regulators and Environmental Stresses on Biomass Production and Artemisinin Concentration of Artemisia annua L.

    • Tariq Aftab, M. Masroor A. Khan, J. F. S. Ferreira

    Pages 157-172

12. Recent Advances to Enhance Yield of Artemisinin: A Novel Antimalarial Compound, in Artemisia annua L. Plants

    • Mauji Ram, D. C. Jain, Himanshu Mishra, Shantanu Mandal, M. Z. Abdin

    Pages 173-204

13. Artemisinin in Cancer Therapy

    • Bianca Ivanescu, Andreia Corciova

    Pages 205-227

14. Recent Developments in Controlling Insect, Acari, Nematode, and Plant Pathogens of Agricultural and Medical Importance by Artemisia annua L. (Asteraceae)

    • Jalal Jalali Sendi, Roya Khosravi

    Pages 229-247

15. Reverse Pharmacology and Drug Discovery: Artemisia annua and Its Anti-HIV Activity

    • Frank van der Kooy

    Pages 249-267

16. Production of Artemisinin In Planta and in Microbial Systems Need Not Be Mutually Exclusive

    • Ebiamadon Andi Brisibe, Peter Nkachukwu Chukwurah

    Pages 269-292

Artemisinin, a sesquiterpene lactone originally extracted from the medicinal plant Artemisia annua L., is an effective antimalarial agent, particularly for multi-drug resistant and cerebral malaria. However, the concentration of artemisinin in the plant is very low. Because the chemical synthesis of artemisinin is complicated and not economically feasible in view of the poor yield of the drug, the intact plant remains the only viable source of artemisinin production. Therefore, it is necessary to increase the concentration of artemisinin in A. annua to reduce the cost of artemisinin based antimalarial drugs. Plant scientists have focused their efforts on A. annua for a higher artemisinin crop yield. With the present volume, we are bringing together the research which is being done on this plant throughout the world and future possibilities for scientists and researchers who want to work on it.

• Artemisinin based Combination Therapies (ACTs)
• antimalarial drug
• artemisinin
• ethnopharmacology
• malaria
• medicinal plant

• Department of Physiology and Cell Biology, Leibniz Institute of Plant Genetics and Crop Plant Research (IPK), Gatersleben, Germany

  Tariq Aftab

• US Salinity Laboratory, United States Department of Agriculture Agriculture Research Service, Riverside, USA

  Jorge F.S. Ferreira

• Botany Department, Aligarh Muslim University, Aligarh, India

  M. Masroor A. Khan, M. Naeem

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