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Salivary Gland Development and Regeneration

Advances in Research and Clinical Approaches to Functional Restoration

  • Book
  • © 2017

Overview

Editors:
  1. Seunghee Cha

    1. Oral and Maxillofacial Diagnostic Sciences, University of Florida, Gainesville, USA

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  • Offers a comprehensive update on latest knowledge in the field
  • Discusses stem cell replacement therapy in depth
  • Examines the latest advances in bioengineering

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Table of contents (13 chapters)

  1. Front Matter

    Pages i-xiii
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  2. Updates on Salivary Gland Development

    1. Front Matter

      Pages 1-1
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    2. Implications of Salivary Gland Developmental Mechanisms for the Regeneration of Adult Damaged Tissues

      • Isabelle M. A. Lombaert
      Pages 3-22

    3. Systems Biology: Salivary Gland Development, Disease, and Regenerative Medicine

      • Melinda Larsen, Petko Bogdanov, Ravi Sood, Hae Ryong Kwon, Deirdre A. Nelson, Connor Duffy et al.
      Pages 23-44

    4. Mucins in Salivary Gland Development, Regeneration, and Disease

      • Isabel Castro, María-José Barrera, Sergio González, Sergio Aguilera, Ulises Urzúa, Juan Cortés et al.
      Pages 45-71

  3. Glandular Damage and Cell Replacement Therapy

    1. Front Matter

      Pages 73-73
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    2. Histologic Changes in the Salivary Glands Following Radiation Therapy

      • Robert S. Redman
      Pages 75-91

    3. Adult Stem Cell Therapy for Salivary Glands, with a Special Emphasis on Mesenchymal Stem Cells

      • Simon D Tran, Yoshinori Sumita, Dongdong Fang, Shen Hu
      Pages 93-102

    4. Directed Cell Differentiation by Inductive Signals in Salivary Gland Regeneration: Lessons Learned from Pancreas and Liver Regeneration

      • Yun-Jong Park, Seunghee Cha
      Pages 103-129

  4. Bioengineering of Salivary Glands

    1. Front Matter

      Pages 131-131
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    2. Current Cell Models for Bioengineering Salivary Glands

      • Olga J. Baker
      Pages 133-144

    3. Matrix Biology of the Salivary Gland: A Guide for Tissue Engineering

      • Mariane Martinez, Danielle Wu, Mary C. Farach-Carson, Daniel A. Harrington
      Pages 145-171

    4. 3D Printing Technology in Craniofacial Surgery and Salivary Gland Regeneration

      • Jong Woo Choi, Namkug Kim, Chang Mo Hwang
      Pages 173-191

    5. Functional Salivary Gland Regeneration by Organ Replacement Therapy

      • Miho Ogawa, Takashi Tsuji
      Pages 193-203

  5. Therapeutic Considerations for Restoration of Salivary Function

    1. Front Matter

      Pages 205-205
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    2. Regulation of Salivary Secretion

      • Guy Carpenter, Polliane Carvalho
      Pages 207-215

    3. Salivary Gland Gene Therapy in Experimental and Clinical Trials

      • Michael Passineau
      Pages 217-228

    4. Surgical Management of Salivary Gland Disease

      • Varun V. Varadarajan, Peter T. Dziegielewski
      Pages 229-263
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Keywords

About this book

This book provides a comprehensive update on the latest information and knowledge which emerged from translational and basic science research endeavors, targeting the regeneration of salivary glands. The coverage includes salivary gland growth and development, stem cell therapy, bioengineering of salivary glands, and perspectives on and practical approaches to restoration of secretory function. More specifically, among the individual topics addressed are the various types of stem cell of value for cell replacement therapy, technological advances with respect to 3D printing, gene therapy, organ culture of salivary glands, and surgical aspects of the feasibility and practicality of transplantation. Readers will find helpful practical guidance on functional restorations of damaged salivary glands and stimulating insights into potential future directions in salivary gland regeneration research. The authors are all acknowledged experts from a range of academic and clinical backgrounds.Accordingly, the book will be of interest not only to clinicians, such as general dental practitioners, oral medicine specialists, and surgeons who manage dry mouth patients, but also to biomedical engineers, stem cell researchers, and transplant surgeons.

Editors and Affiliations

  • Oral and Maxillofacial Diagnostic Sciences, University of Florida, Gainesville, USA

    Seunghee Cha

About the editor

Seunghee Cha, DDS, PhD, is an Associate Professor in the Section of Oral Medicine and Joint Associate Professor in Oral Biology, Department of Oral and Maxillofacial Diagnostic Sciences, University of Florida College of Dentistry. Dr. Cha is actively involved in basic and clinical science research while serving leadership roles in various international scientific communities. Her main research interests include the pathogenesis of autoimmune Sjӧgren’s syndrome (SjS) and cell replacement therapy for dry mouth. Her current and future studies are focusing on the pathological roles of anti-M3R autoantibodies in SjS hyposalivation, the pro-inflammatory microenvironment in the salivary glands for target tissue specificity, microRNA expression and its functions in innate immunity of SjS, identification of susceptibility genes by application of functional genomics and proteomics, application of receptor-mediated siRNA delivery in SjS, and development of preventive and therapeutic strategies for dry mouth. Dr. Cha has published extensively in peer-reviewed international journals.

Bibliographic Information

  • Book Title: Salivary Gland Development and Regeneration

  • Book Subtitle: Advances in Research and Clinical Approaches to Functional Restoration

  • Editors: Seunghee Cha

  • DOI: https://doi.org/10.1007/978-3-319-43513-8

  • Publisher: Springer Cham

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Springer International Publishing Switzerland 2017

  • Hardcover ISBN: 978-3-319-43511-4Published: 03 March 2017

  • Softcover ISBN: 978-3-319-82843-5Published: 13 July 2018

  • eBook ISBN: 978-3-319-43513-8Published: 20 February 2017

  • Edition Number: 1

  • Number of Pages: XIII, 263

  • Number of Illustrations: 5 b/w illustrations, 47 illustrations in colour

  • Topics: Dentistry, Oral and Maxillofacial Surgery, Biomedical Engineering/Biotechnology, Stem Cells

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