Skip to main content
SpringerLink
Log in

Metal Response in Cupriavidus metallidurans

Volume I: From Habitats to Genes and Proteins

  • Book
  • © 2015

Overview

Editors:
  1. Max Mergeay

    1. Unit of Microbiology, Belgium Nuclear Research Centre, Mol, Belgium

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  2. Rob Van Houdt

    1. Unit of Microbiology, Belgium Nuclear Research Centre, Mol, Belgium

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • A detailed overview of the diversity of metal resistance and homeostasis systems
  • Their general context related to mobile genetic elements and horizontal gene transfer
  • The underlying regulatory network and crosstalk within this network
  • Catalytic and three-dimensional structural insights
  • Includes supplementary material: sn.pub/extras

Part of the book series: SpringerBriefs in Molecular Science (BRIEFSMOLECULAR)

Part of the book sub series: SpringerBriefs in Biometals (SB BIOMETALS)

This is a preview of subscription content, log in via an institution to check access.

Access this book

Log in via an institution
eBook USD 39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access

Licence this eBook for your library

Institutional subscriptions

Table of contents (3 chapters)

  1. Front Matter

    Pages i-ix
    Download chapter PDF

  2. The History of Cupriavidus metallidurans Strains Isolated from Anthropogenic Environments

    • Max Mergeay
    Pages 1-19

  3. Genomic Context of Metal Response Genes in Cupriavidus metallidurans with a Focus on Strain CH34

    • Rob Van Houdt, Max Mergeay
    Pages 21-44

  4. Response of Cupriavidus metallidurans CH34 to Metals

    • Pieter Monsieurs, Jon Hobman, Guy Vandenbussche, Max Mergeay, Rob Van Houdt
    Pages 45-89
Back to top

Keywords

About this book

This book is the first volume of a two-volume set summarizing 40 years of key research findings directly related to metal-resistant Cupriavidus/Ralstonia (Betaproteobacteria). In this first volume, the historical and geographical context of these bacteria, which are mostly found in industrial and polluted environments linked to zinc and other non-ferrous metallurgy, is sketched to illustrate the interactions between bacteria and human activities and the possible evolutionary consequences on bacterial genomes especially as far as the association of metal resistance genes with mobile genetic elements is concerned. A detailed description of the response and underlying genetic determinants of type strain Cupriavidus metallidurans CH34 to a variety of metals is provided. With high level resistance to cadmium, chromate, cobalt, copper, mercury, nickel, lead and zinc mediated by well-known genes for detoxification carried by its megaplasmids pMOL28 and pMOL30. This description is complemented with the genomic context of the metal response genes in C. metallidurans CH34 with a focus on its mobilome including insertion sequence elements, transposons, integrative and conjugative elements and genomic islands. In addition, in the second volume, structural and catalytic data from bacterial primary and secondary transporters (P-ATPases, tripartite chemiosmotic cation/proton efflux systems, cation diffusion facilitators, Major Facilitator Superfamily and some minor categories) are outlined and detailed for the corresponding C. metallidurans proteins. The available three-dimensional structures of C. metallidurans proteins are reviewed in detail, including RND and membrane fusion proteins (from tripartite chemiosmotic cation/proton efflux systems), sigma and anti-sigma regulatory proteins of the cnr efflux system (resistance to cobalt and nickel) and various periplasmic proteins mainly involved in the response to copper andmercury.

Editors and Affiliations

  • Unit of Microbiology, Belgium Nuclear Research Centre, Mol, Belgium

    Max Mergeay, Rob Van Houdt

Bibliographic Information

Publish with us

Policies and ethics

Back to top

Search

Navigation