Nano-Biomaterials For Ophthalmic Drug Delivery

1. Front Matter

   Pages i-xix

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2. Introduction to Nanotechnology with Special Reference to Ophthalmic Delivery

   • Anjali Hirani, Yashwant Pathak

   Pages 1-8

3. Overview of the Ophthalmic System

   • Sharad Malavade

   Pages 9-36

4. Pharmacological Considerations in Ophthalmic Drug Delivery

   • Nikhil A. Sangave, Charles Preuss, Yashwant Pathak

   Pages 37-56

5. Pathophysiology of Vision

   • Orhan E. Arslan

   Pages 57-81

6. Nanotechnology and Nanomaterials in Ophthalmic Drug Delivery

   • Shengyan Liu, Lyndon W. Jones, Frank X. Gu

   Pages 83-109

7. Pharmacokinetics and Pharmacodynamics of Ocular Drugs

   • Vivek S. Dave, Suraj G. Bhansali

   Pages 111-129

8. Physicochemical Requirements for Polymers and Polymer-Based Nanomaterial for Ophthalmic Drug Delivery

   • Sheeba Varghese Gupta

   Pages 131-146

9. Formulation Approaches for Ocular Drug Delivery

   • Vivek S. Dave

   Pages 147-175

10. Ocular Permeation Enhancers

    • Nathaniel J. Kim, Alon Harris, Alhasan Elghouche, Willy Gama, Brent Siesky

    Pages 177-209

11. Ocular Bioadhesives and Their Applications in Ophthalmic Drug Delivery

    • Rakesh K. Tekade, Muktika Tekade

    Pages 211-230

12. Nanovesicular Carrier Systems for Ophthalmic Drug Delivery

    • Lipika Chablani, Vijay Kumar

    Pages 231-242

13. Cyclodextrins in Ocular Drug Delivery

    • Sridhar Anand, Vanildo Martins Lima Braga

    Pages 243-252

14. Ocular Preservatives: Risks and Recent Trends in Its Application in Ocular Drug Delivery (ODD)

    • Sabyasachi Maiti, Sayantan Sadhukhan, Paromita Bakshi

    Pages 253-276

15. Aging Disorders of the Eye: Challenges and Approaches for Their Treatment

    • Shruti Hazare, Rongbing Yang, Smita Chavan, Mala D. Menon, Mahavir B. Chougule

    Pages 277-320

16. Colloidal Carriers in Ophthalmic Drug Delivery

    • Deepak Gupta

    Pages 321-349

17. Polymeric Nanoparticulate Systems: A Potential Approach for Ocular Drug Delivery

    • Rutika Godse, Kavita Singh, Agnivesh Shrivastava, Ujwala Shinde

    Pages 351-387

18. Barriers to Glaucoma Drug Delivery and Resolving the Challenges Using Nanotechnology

    • Morgan V. Fedorchak

    Pages 389-406

19. Intraocular Drug Delivery Technologies: Advancing Treatment of Posterior Segment Disorders of the Eye

    • Viness Pillay, Yahya E. Choonara, Lisa C. du Toit

    Pages 407-460

20. Animal Models to Evaluate Nanoparticulate Ocular Drug Delivery Systems

    • Amy Broadwater, Anjali Hirani, Yashwant Pathak

    Pages 461-469

This consolidated reference book addresses the various aspects of nano biomaterials used in ophthalmic drug delivery, including their characterization, interactions with ophthalmic system and applications in treatments of the ophthalmic diseases and disorders. In the last decade, a significant growth in polymer sciences, nanotechnology and biotechnology has resulted in the development of new nano- and bioengineered nano-bio-materials. These are extensively explored as drug delivery carriers as well as for implantable devices and scaffolds. At the interface between nanomaterials and biological systems, the organic and synthetic worlds merge into a new science concerned with the safe use of nanotechnology and nano­ material design for biological applications. For this field to evolve, there is a need to understand the dynamic forces and molecular components that shape these interactions. While it is impossible to describe with certainty all the bio­ physicochemical interactions at play at the interface, we are at a point where the pockets of assembled knowledge are providing a conceptual framework to guide this exploration, and review the impact on future product development. The book is intended as a valuable resource for academics and pharmaceutical scientists working in the field of polymers, polymers materials for drug delivery, drug delivery systems and ophthalmic drug delivery systems, in addition to medical and health care professionals in these areas.

• Colloidal carrier polymers
• Intra vitreal implants
• Nano vesicular carriers
• Ocular Diseases
• Ocular insert polymers
• Ocular pharmacotherapy

• College of Pharmacy, University of South Florida Health, Tampa, USA

  Yashwant Pathak, Vijaykumar Sutariya

• College of Pharmacy, University of South Florida, Tampa, USA

  Anjali A. Hirani

Yashwant Pathak, M.Pharm., EMBA, MS (Conflict Management), Ph.D.


Dr. Yashwant Pathak completed his M.S. and Ph.D. in Pharmaceutical Technology from Nagpur University, India and EMBA and MS in Conflict Management from Sullivan University, Louisville, KY. He is the Associate Dean for Faculty Affairs at College of Pharmacy, University of South Florida in Tampa, FL. With extensive experience in academia as well as industry, he has more than 100 publications, 2 patents applications, 5 books in Nanotechnology and 4 in Nutraceuticals and several books in cultural studies. His areas of research include drug delivery systems and its characterization in animal models.


Vijaykumar Sutariya, B.Pharm., M.Pharm., Ph.D.


Dr. Vijaykumar Sutariya received his Bachelors and Masters in Pharmacy from L. M. College of Pharmacy, Gujarat University, Ahmedabad, India and Ph.D. in Pharmacy from The M.S. University of Baroda, Vadodara, India. He did his postdoctoral training in pharmaceutics and drug delivery at Butler University, Indianapolis, IN. Dr. Sutariya is an Assistant Professor in the Department of Pharmaceutical Sciences at the USF College of Pharmacy. He has a joint appointment with the Department of Internal Medicine, Division of Translational Medicine at USF. Dr. Sutariya’s research is focused on development of novel drug delivery systems such as nanoparticles, liposomes and thermoreversible gels. 


Anjali Hirani, Ph.D.
Dr. Anjali Hirani received her M.S. and Ph.D. in Biomedical Engineering from Virginia Tech, Blacksburg, VA. She is currently a postdoctoral fellow at the University of South Florida in the College of Pharmacy. Her research is focused on the development of sustained drug delivery systems for ocular disease. 

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