Human iPS Cells in Disease Modelling

1. Front Matter

   Pages i-vii

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2. Recent Improvements and Emerging Issues in iPSC Generation for the Modeling of Disease

   • Tomohisa Seki, Shinsuke Yuasa, Keiichi Fukuda

   Pages 1-9

3. Cardiomyopathy

   • Elena Matsa, Karim Sallam, Joseph C. Wu

   Pages 11-26

4. Modeling Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy with Patient-Specific iPSCs

   • K. Shah, C.-Y. Wei, C.-S. Kim, J. Wong, J.-Y. Wen, T. Tirasawasdichai et al.

   Pages 27-43

5. Cardiac Arrhythmia Modelling Using iPS Cells

   • Shinsuke Yuasa

   Pages 45-51

6. iPSC Disease Modeling of Laminopathies

   • Guang-Hui Liu, Jiping Yang, Zhichao Ding, Alejandro Ocampo, Jing Qu, Keiichiro Suzuki et al.

   Pages 53-67

7. Hematological Disorders

   • Megumu K. Saito, Akira Niwa

   Pages 69-81

8. Inherited Metabolic Disorders of the Liver

   • Charis-P. Segeritz, Ludovic Vallier

   Pages 83-99

Human iPS cells have a great potential to be cell sources for regenerative medicine because of the promise of infinite self-renewal and the capability to differentiate into multiple cell types. This book focuses on another great potential of human iPS cells, which is the establishment of human disease models using patient-specific iPS cells. Human iPS cells can be easily obtained from a patient’s somatic cells and provide the entire information on the patient’s genome. Accordingly, we can generate disease models for inheritable diseases in cell culture dishes using iPS cells. This is a quite new technique but holds tremendous potential for our increased understanding of pathogenesis, and will then be the basis for novel drug development industries. All the authors are leading researchers in this field and they have reported many kinds of patient-derived iPS cells. In this book, they introduce the aspects that could be recapitulated in terms of disease modelling as well as further innovative findings such as novel pathogenetic insights and novel therapies. 

• cell reprogramming
• iPS cell
• iPSCs
• induced pluripotent stem cells
• stem cel biology
• ES cell
• disease modeling
• Cell culture

• Keio University School of Medicine, Department of Cardiology, Tokyo, Japan

  Keiichi Fukuda

Dr. Keiichi Fukuda obtained PhD degree in Division of Medicine, Keio University Graduate School, Japan in 1987. He started his carrier as an assistant Professor at Keio University, and promoted to full Professor in 2005. He is one of the top scientists in Japan and renowned as he had established a new therapy using regenerated cardiomyocytes obtained from stem cells.

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