Necrotic Cell Death

1. Front Matter

   Pages i-xiv

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2. The Potential Role of Necroptosis in Diseases

   • Andreas Linkermann, Tom Vanden Berghe, Nozomi Takahashi, Ulrich Kunzendorf, Stefan Krautwald, Peter Vandenabeele

   Pages 1-21

3. RIP1-Mediated Signaling Pathways in Cell Survival and Death Control

   • Yong Lin

   Pages 23-43

4. Role of RIP3 in Necrotic Cell Death

   • Ting Wu, Wanze Chen, Jiahuai Han

   Pages 45-55

5. IAPs and Necroptotic Cell Death

   • John Silke, David Vaux

   Pages 57-77

6. Regulation of Death Receptor-Induced Necroptosis by Ubiquitination

   • Maurice Darding, Henning Walczak

   Pages 79-97

7. Dead if You Do, Dead if You Don’t: How Caspase-8 Causes and Prevents Cell Death

   • Andrew Oberst

   Pages 99-116

8. The In Vivo Significance of Necroptosis: Lessons from Exploration of Caspase-8 Function

   • David Wallach, Tae-Bong Kang, Akhil Rajput, Seung-Hoon Yang, Jin-Chul Kim, Beata Toth et al.

   Pages 117-133

9. NOX1, Reactive Oxygen Species, JNK, and Necrotic Cell Death

   • Michael J. Morgan, You-Sun Kim

   Pages 135-162

10. PARP Activation and Necrotic Cell Death

    • Yongjun Fan, Wei-Xing Zong

    Pages 163-175

11. Programmed Necrosis in Immunity and Inflammatory Diseases

    • Kenta Moriwaki, Francis Ka-Ming Chan

    Pages 177-194

12. p53 Opens the Mitochondrial Permeability Transition Pore to Trigger Necrosis in Response to Oxidative Damage

    • Katharina Zirngibl, Ute M. Moll

    Pages 195-209

13. Autophagic Cell Death: A Real Killer, an Accomplice, or an Innocent Bystander?

    • Shi-Hao Tan, Han-Ming Shen

    Pages 211-232

14. Autophagy in Necrosis: A Force for Survival

    • Han-Ming Shen, Patrice Codogno

    Pages 233-252

15. Microbial Programmed Necrosis: The Cost of Conflicts Between Stress and Metabolism

    • Joris Winderickx, Paula Ludovico

    Pages 253-274

16. Necrotic Cell Death in Caenorhabditis elegans

    • Vassiliki Nikoletopoulou, Nektarios Tavernarakis

    Pages 275-294

17. Necrostatin-1: Its Discovery and Application in Cell Death Research

    • Dana E. Christofferson, Ying Li, Junying Yuan

    Pages 295-318

18. Small-Molecule Inhibitors of Necroptosis

    • Colleen R. McNamara, Alexei Degterev

    Pages 319-334

19. Methods to Study and Distinguish Necroptosis

    • Sasker Grootjans, Vera Goossens, Peter Vandenabeele, Tom Vanden Berghe

    Pages 335-361

20. Back Matter

    Pages 363-397

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Starting with discussion of basic concepts and the molecular mechanisms of necrosis, this book looks first at several forms of necrotic cell death that have been identified, including necroptosis, autophagic cell death, and PARP-mediated cell death. As necrotic cell death is increasingly known to play a critical role in many physiological processes, the next chapters discuss its effect on metabolism, inflammation, immunity, and development. Necrotic cell death is closely implicated in human diseases like cancer, so the next chapters examine its relevance to human diseases, and final chapters cover methodologies for measuring necrosis. This book presents comprehensive coverage of necrosis from recognized experts from leading academic and medical institutions around the world. ​In contrast to apoptosis, well-defined as a form of programmed cell death, necrosis used to be considered as accidental (i.e., non-programmed) cell death, usually in response to a severe injury. Accumulating evidence now suggests, however, that necrosis is also programmed and controlled by distinctive "death machinery" in response to various stimuli like oxidative stress or DNA damage.

• Apoptosis
• Cell death
• Necrosis
• Necrotic cell death
• Oxidative stress
• Cell Cycle Analysis

• Department of Physiology, National University of Singapore Yong Loo Lin School of Medicine, Singapore, Singapore

  Han-Ming Shen

• Department of Biomedical Molecular Biology (UGent), VIB/University of Ghent Inflammation Research Center (VIB), Zwijnaarde, Belgium

  Peter Vandenabeele

Dr. Han-Ming Shen is currently Associate Professor in the Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore. He received his Ph.D. from the National University of Singapore and holds a Master of Medicine from Zhejiang Medical University, China. Winner of several academic and scientific awards, Dr. Shen’s main research interests include autophagy in cell death and cancer, involvement of reactive oxygen/nitrogen species and oxidative stress in cell death signaling pathways (apoptotic and non-apoptotic cell death), and antioxidants and natural products as anti-cancer agents.

Dr. Peter Vandenabeele obtained his PhD in Biology in the lab of Prof. Walter Fiers at Ghent University in Belgium. Currently, he is a Primary Investigator at the Flanders Institute for Biotechnology (VIB) and a Senior Professor at Ghent University where he also served for ten years as Director of the Bachelor’s and Master’s program in Biochemistry and Biotechnology and still serves on the Board of Governors.  His research focuses on molecular mechanisms of cell death and inflammation with focus on necrotic cell death which is studied in an integrated way at biochemical, cell biological and experimental disease level. Dr. Vandenabeele has also twice been chairman of the Euroconference on Apoptosis, organized by the European Cell Death Organization (ECDO).

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