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Chimerism

A Clinical Guide

  • Book
  • © 2018

Overview

Editors:
  1. Nicole L. Draper

    1. Department of Pathology, University of Colorado School of Medicine, Aurora, USA

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  • Valuable resource for clinicians and researchers that will help guide patient management and stimulate investigative efforts

  • Presented in an easy-to-read format

  • Written by experts in the field

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Table of contents (11 chapters)

  1. Front Matter

    Pages i-xi
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  2. Causes of Chimerism in Humans

    1. Front Matter

      Pages 1-1
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    2. Fertilization and Early Embryonic Errors

      • Nicole L. Draper, Kristy Crooks
      Pages 3-17

    3. Pregnancy and Multiple Gestations

      • Linda Marie Randolph, Ramen H. Chmait
      Pages 19-31

    4. Transplantation and Transfusion

      • Joel N. Kniep
      Pages 33-48

  3. Clinical Identification and Consequences of Chimerism

    1. Front Matter

      Pages 49-49
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    2. Relationship Testing and Forensics

      • Kayla Sheets, Robert Wenk
      Pages 51-63

    3. Prenatal Genetic Testing and Screening

      • Ignatia B. Van den Veyver
      Pages 65-79

    4. Blood Typing Discrepancies

      • Opal L. Reddy, Dawn C. Ward, Andrea M. McGonigle
      Pages 81-103

    5. Hematopoietic Stem Cell Donor Selection and Graft-Versus-Host Disease

      • Alexa J. Siddon, Christopher A. Tormey
      Pages 105-117

    6. Passenger Lymphocyte Syndrome

      • Nicole L. Draper, Jamie E. Kallan
      Pages 119-134

    7. Chimerism: A Clinical Guide to Tolerance Induction

      • Andrea R. Merchak, Anita Y. Chhabra, Joseph R. Leventhal, Suzanne T. Ildstad
      Pages 135-152

    8. Autoimmune Disease

      • Nathalie Lambert
      Pages 153-179

    9. Cancer

      • Valentina Cirello, Laura Fugazzola
      Pages 181-194

  4. Back Matter

    Pages 195-200
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Keywords

About this book

This text provides a comprehensive, up-to-date review of chimerism. The first part of the volume presents the causes of chimerism, specifically focusing on fertilization and early embryonic errors, pregnancy and multiple gestations, and transplantation and transfusion. The second part of the volume outlines clinical identification and consequences of chimerism. Chapters in this section focus on the effects of chimerism on testing in relationship determination and forensics, prenatal genetic testing and screening, and blood and HLA typing. This part also reviews new data concerning matching donors and recipients for transplantation, while outlining the risks of transplantation, such as graft-vs-host disease and passenger lymphocyte syndrome.  Additionally, evidence on the role of chimerism in autoimmune disease and cancer is presented.  


Written by experts in the field, Chimerism: A Clinical Guide is a valuable resource for clinicians and researchers that will help guide patient management and stimulate investigative efforts.



Reviews

“The purpose is to provide a single source of the ‘current understanding of chimerism.’ This worthy objective is well met by this book. … This book would be of interest to anyone working in blood bank/transfusion services or molecular genetic testing, general anatomical pathologists and specialists in forensics, autoimmune and/or obstetrical pathology. … This is a fantastic book and a fascinating read. You will quickly get up to speed in an esoteric area which surprisingly impacts many aspects of medicine.” (Valerie L. Ng, Doody's Book Reviews, November, 2018)

Editors and Affiliations

  • Department of Pathology, University of Colorado School of Medicine, Aurora, USA

    Nicole L. Draper

About the editor

Nicole L. Draper, MD
University of Colorado School of Medicine
Department of Pathology
Aurora, CO 
USA

Bibliographic Information

  • Book Title: Chimerism

  • Book Subtitle: A Clinical Guide

  • Editors: Nicole L. Draper

  • DOI: https://doi.org/10.1007/978-3-319-89866-7

  • Publisher: Springer Cham

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Springer International Publishing AG, part of Springer Nature 2018

  • Hardcover ISBN: 978-3-319-89865-0Published: 12 July 2018

  • Softcover ISBN: 978-3-030-07881-2Published: 14 December 2018

  • eBook ISBN: 978-3-319-89866-7Published: 21 June 2018

  • Edition Number: 1

  • Number of Pages: XI, 200

  • Number of Illustrations: 5 b/w illustrations, 15 illustrations in colour

  • Topics: Hematology, Blood Transfusion Medicine

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