Overview
- Editors:
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Keiichi Fukuda
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Keio University School of Medicine, Department of Cardiology, Tokyo, Japan
- how human disease models are established by patient-derived iPS Cells
- a wide range of human diseases such as cardiomyopathy, laminopathy, and Alzheimer’s
- Is written
by top scientists in the field of iPS cells technology
- Includes supplementary material: sn.pub/extras
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Table of contents (7 chapters)
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- Tomohisa Seki, Shinsuke Yuasa, Keiichi Fukuda
Pages 1-9
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- Elena Matsa, Karim Sallam, Joseph C. Wu
Pages 11-26
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- K. Shah, C.-Y. Wei, C.-S. Kim, J. Wong, J.-Y. Wen, T. Tirasawasdichai et al.
Pages 27-43
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- Guang-Hui Liu, Jiping Yang, Zhichao Ding, Alejandro Ocampo, Jing Qu, Keiichiro Suzuki et al.
Pages 53-67
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- Megumu K. Saito, Akira Niwa
Pages 69-81
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- Charis-P. Segeritz, Ludovic Vallier
Pages 83-99
About this book
Human iPS cells have a great potential to be cell sources for
regenerative medicine because of the promise of infinite self-renewal and the
capability to differentiate into multiple cell types. This book focuses on
another great potential of human iPS cells, which is the establishment of human
disease models using patient-specific iPS cells. Human iPS cells can be easily
obtained from a patient’s somatic cells and provide the entire information on the
patient’s genome. Accordingly, we can generate disease models for inheritable
diseases in cell culture dishes using iPS cells. This is a quite new technique
but holds tremendous potential for our increased understanding of pathogenesis,
and will then be the basis for novel drug development industries. All the
authors are leading researchers in this field and they have reported many kinds
of patient-derived iPS cells. In this book, they introduce the aspects that
could be recapitulated in terms of disease modelling as well as further
innovative findings such as novel pathogenetic insights and novel therapies.
Editors and Affiliations
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Keio University School of Medicine, Department of Cardiology, Tokyo, Japan
Keiichi Fukuda
About the editor
Dr. Keiichi Fukuda obtained PhD degree in Division of Medicine, Keio University Graduate School, Japan in 1987. He started his carrier as an assistant Professor at Keio University, and promoted to full Professor in 2005. He is one of the top scientists in Japan and renowned as he had established a new therapy using regenerated cardiomyocytes obtained from stem cells.
