Skip to main content
SpringerLink
Log in
Book cover

T Lymphocytes as Tools in Diagnostics and Immunotoxicology

  • Book
  • © 2014

Overview

Editors:
  1. Stefan F. Martin

    1. Department of Dermatology and Venereology, University Medical Center Freiburg, Freiburg, Germany

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • Alternative assays for the detection of contact allergens and drug metabolites
  • Summarizes the state-of-the art
  • Written by experts in the field
  • Includes supplementary material: sn.pub/extras

Part of the book series: Experientia Supplementum (EXS, volume 104)

This is a preview of subscription content, log in via an institution to check access.

Access this book

Log in via an institution
eBook USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access

Licence this eBook for your library

Institutional subscriptions

Table of contents (11 chapters)

  1. Front Matter

    Pages i-vi
    Download chapter PDF

  2. The Use of T Cells in Hazard Characterization of Chemical and Drug Allergens and Integration in Testing Strategies

    • Ian Kimber, Marc Pallardy
    Pages 1-7

  3. Activation of the TCR Complex by Peptide-MHC and Superantigens

    • Christine Louis-Dit-Sully, Britta Blumenthal, Marlena Duchniewicz, Katharina Beck-Garcia, Gina J. Fiala, Esmeralda Beck-García et al.
    Pages 9-23

  4. Activation of the TCR Complex by Small Chemical Compounds

    • Christine Louis-Dit-Sully, Wolfgang W. A. Schamel
    Pages 25-39

  5. T Cell Responses to Contact Allergens

    • Hans Ulrich Weltzien, Stefan F. Martin, Jean-François Nicolas
    Pages 41-49

  6. Contact Hypersensitivity: Quantitative Aspects, Susceptibility and Risk Factors

    • Peter S. Friedmann, Christopher Pickard
    Pages 51-71

  7. Tools and Methods for Identification and Analysis of Rare Antigen-Specific T Lymphocytes

    • Stefan F. Martin, Sonja S. Schmucker, Anne Richter
    Pages 73-88

  8. Human T Cell Priming Assay: Depletion of Peripheral Blood Lymphocytes in CD25+ Cells Improves the In Vitro Detection of Weak Allergen-Specific T Cells

    • Marc Vocanson, Amine Achachi, Virginie Mutez, Magalie Cluzel-Tailhardat, Béatrice Le Varlet, Aurore Rozières et al.
    Pages 89-100

  9. Correlation of Contact Sensitizer Potency with T Cell Frequency and TCR Repertoire Diversity

    • Philipp R. Esser, Ian Kimber, Stefan F. Martin
    Pages 101-114

  10. On the Role of Co-inhibitory Molecules in Dendritic Cell: T Helper Cell Coculture Assays Aimed to Detect Chemical-Induced Contact Allergy

    • Matthias Peiser, Manuel Hitzler, Andreas Luch
    Pages 115-135

  11. T Cell Responses to Drugs and Drug Metabolites

    • C. J. Earnshaw, T. Pecaric-Petkovic, B. K. Park, D. J. Naisbitt
    Pages 137-163

  12. Hypersensitivity Reactions to Beta-lactams

    • Maria J. Torres, Cristobalina Mayorga, Natalia Blanca-López, Miguel Blanca
    Pages 165-184
Back to top

Keywords

About this book

This book summarizes the state-of-the art in the development of T cell-based in vitro assays, which offer useful tools for hazard identification, risk assessment and improvement of diagnostics. It will be of interest to scientists, the chemical and pharmaceutical industry, and regulators involved in the replacement of animal testing methods.

The identification of hazardous chemicals and drugs is essential to ensuring human health. The ban on animal testing for the cosmetics industry since 2009 and international efforts to reduce and replace animal testing in research and immunotoxicology call for alternative in vitro methods. The most specific immune response to chemicals and drugs that cause allergic contact dermatitis, respiratory disease and adverse drug reactions is the highly antigen-specific T lymphocyte response. Therefore the use of T cells as tools for identifying contact allergens and drugs that may cause health problems is of great interest.

Editors and Affiliations

  • Department of Dermatology and Venereology, University Medical Center Freiburg, Freiburg, Germany

    Stefan F. Martin

Bibliographic Information

  • Book Title: T Lymphocytes as Tools in Diagnostics and Immunotoxicology

  • Editors: Stefan F. Martin

  • Series Title: Experientia Supplementum

  • DOI: https://doi.org/10.1007/978-3-0348-0726-5

  • Publisher: Springer Basel

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer Basel 2014

  • Hardcover ISBN: 978-3-0348-0725-8Published: 21 November 2013

  • eBook ISBN: 978-3-0348-0726-5Published: 09 November 2013

  • Series ISSN: 1664-431X

  • Series E-ISSN: 2504-3692

  • Edition Number: 1

  • Number of Pages: VI, 184

  • Number of Illustrations: 6 b/w illustrations, 21 illustrations in colour

  • Topics: Molecular Medicine, Immunology, Laboratory Medicine

Publish with us

Policies and ethics

Back to top

Search

Navigation