PET and SPECT of Neurobiological Systems

1. Front Matter

   Pages i-xviii

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2. Basics

   1. Front Matter

      Pages 1-1

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   2. Animal Models for Brain Research

      • Debby Van Dam, Peter Paul De Deyn

      Pages 3-46

   3. Small Animal Molecular Imaging Through μPET and μSPECT

      • Steven Staelens, Tine Wyckhuys, Steven Deleye, Jeroen Verhaeghe, Leonie Wyffels, Sigrid Stroobants

      Pages 47-84

   4. Cerebral Glucose Metabolism

      • Wolf-Dieter Heiss

      Pages 85-101

   5. Cerebral Blood Flow Measurement with Oxygen-15 Water Positron Emission Tomography

      • Vilia Zeisig, Marianne Patt, Georg Becker, Johannes Boltze, Osama Sabri, Henryk Barthel

      Pages 103-124

   6. Principles of Brain Perfusion SPECT

      • Shana Elman, David H. Lewis

      Pages 125-147

   7. The Impact of Genetic Polymorphisms on Neuroreceptor Imaging

      • Matthäus Willeit, Siegfried Kasper, Nicole Praschak-Rieder

      Pages 149-178

3. Systems

   1. Front Matter

      Pages 179-179

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   2. Imaging of Adenosine Receptors

      • David Elmenhorst, Dirk Bier, Marcus Holschbach, Andreas Bauer

      Pages 181-198

   3. PET Tracers for Beta-Amyloid and Other Proteinopathies

      • Agneta Nordberg

      Pages 199-212

   4. Imaging of Central Benzodiazepine Receptors in Chronic Cerebral Ischemia

      • Hiroshi Yamauchi

      Pages 213-227

   5. PET and SPECT Imaging of the Central Dopamine System in Humans

      • Jan Booij, Jan-Peter van Wieringen, Elsmarieke van de Giessen, Remco J. J. Knol, Sjoerd J. Finnema

      Pages 229-248

   6. PET Imaging of Endocannabinoid System

      • Andrew G. Horti, Vanessa Raymont, Garth E. Terry

      Pages 249-319

   7. Imaging Type 1 Glycine Transporters in the CNS Using Positron Emission Tomography

      • Jan Passchier, Roger N. Gunn, Aren van Waarde

      Pages 321-330

   8. Imaging Histamine Receptors Using PET and SPECT

      • Uta Funke, Danielle J. Vugts, Bieneke Janssen, Arnold Spaans, Perry S. Kruijer, Adriaan A. Lammertsma et al.

      Pages 331-376

   9. PET and SPECT Imaging of Steroid Hormone Receptors

      • Mohammed A. Khayum, Janine Doorduin, Andor W. J. M. Glaudemans, Rudi A. J. O. Dierckx, Erik F. J. de Vries

      Pages 377-408

   10. Current Radioligands for the PET Imaging of Metabotropic Glutamate Receptors

       • Linjing Mu, Simon M. Ametamey

       Pages 409-443

   11. PET Imaging of Muscarinic Receptors

       • Hideo Tsukada

       Pages 445-464

   12. Preclinical Aspects of Nicotinic Acetylcholine Receptor Imaging

       • Peter Brust, Winnie Deuther-Conrad, Cornelius K. Donat, Henryk Barthel, Patrick Riss, Louise Paterson et al.

       Pages 465-512

PET and SPECT of Neurobiological Systems combine the expertise of authors internationally renowned for their dedication to the development of novel probes and techniques for the investigation of neurobiological systems. Various aspects of neurotransmission in the brain are discussed, such as visualization and quantification of neuroreceptors, neuroinflammatory markers, transporters and enzymes as well as neurotransmitter synthesis, β-amyloid deposition, cerebral blood flow and the metabolic rate of glucose. The latest results in probe development are also detailed. Most chapters are written jointly by radiochemists and nuclear medicine specialists to ensure a multidisciplinary approach. This state-of-the-art compendium will be valuable to all with an interest in the field of clinical or preclinical neuroscience. Other volumes focus on PET and SPECT in psychiatry and PET and SPECT in neurology".

• In Vivo Quantification
• Nuclear Medicine
• Radiochemistry

“This is the best comprehensive reference regarding the Functional Imaging of Neurosystems including neurological and psychiatric disorders. … I recommend this reference and nuclear medicine review book for radiologists and researchers. Scientists in PET research will also benefit from the A-z approaches.” (Joseph J. Grenier, Amazon.com, June, 2015)

“This volume explores in detail the most important aspects of the functioning brain … . The book is therefore ardently suggested to a wide audience represented by all those who work in neurosciences, such as neurologists, psychiatrists, geriatricians, nuclear physicians, neuroradiologists, psychologists and so on; the book could also be interesting for practitioners and basic researchers; finally, representing a strong stimulus to intelligence, it is suggested to all students who want to acquire advanced bases on neuroimaging … .” (Gianluca de Matteis and Luigi Mansi, European Journal of Nuclear Medicine and Molecular Imaging, Vol. 42, 2015)

• Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, Groningen, The Netherlands

  Rudi A.J.O. Dierckx, Erik F.J. de Vries, Aren van Waarde

• Faculty of Electrical Engineering and Information Technology, University of Applied Sciences Offenburg, Offenburg, Germany

  Andreas Otte

• Molecular Neurobiology, Universtiy of Groningen, Groningen, The Netherlands

  Paul G.M. Luiten

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