Epigenetic Advancements in Cancer

1. Front Matter

   Pages i-xi

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2. Epigenetic Control of Genes Involved in Cancer Initiation and Progression

   • Sabita N. Saldanha, Shivani Soni

   Pages 1-26

3. Epigenetic Changes and Potential Targets in Pancreatic Cancer

   • Rajesh Singh, James W. Lillard Jr., Shailesh Singh

   Pages 27-63

4. Epigenetic and Cancer: An Evaluation of the Impact of Dietary Components

   • James A. Stokes III, Sanjay Kumar, Karyn Scissum-Gunn, Udai P. Singh, Manoj K. Mishra

   Pages 65-78

5. Gene Expression, Epigenetic Regulation, and Cancer

   • Shuntele N. Burns

   Pages 79-96

6. Epigenetics of Colorectal Cancer

   • Kumar S. Bishnupuri, Manoj K. Mishra

   Pages 97-121

7. Epigenesis in Colorectal Cancer: A Lethal Change in the Cell

   • Rashmi K. Ambasta, Dhiraj Kumar, Piyush Sawhney, Rajat Gupta, Parul Yadav, Pooja Pabari et al.

   Pages 123-144

8. Epigenetics and Angiogenesis in Cancer

   • Niraj Kumar Jha, Saurabh Kumar Jha, Satyaprakash, Rohan Kar, Deepak Rathore, Rashmi K. Ambasta et al.

   Pages 145-176

9. Epigenetic Post transcriptional Mutation in Neuro-Oncology

   • Ankit Tripathi, Renu Sharma, Noopur Kejriwal, Rashmi K. Ambasta, Pravir Kumar

   Pages 177-205

10. Epigenetics of Breast Cancer: DNA Methylome and Global Histone Modifications

    • Gulistan Mese, Ozden Yalcin-Ozuysal

    Pages 207-228

11. Enhancer of Zeste Homology 2 (Ezh2), an Epigenetic Regulator: A Possibility for Prostate Cancer Treatment

    • Sanjay Kumar, James A. Stokes III, Udai P. Singh, Kumar S. Bishnupuri, Manoj K. Mishra

    Pages 229-244

12. Back Matter

    Pages 245-246

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This volume explores the epigenetic alterations and their association with various human cancers. Considering one of human cancer as an example, individual chapters are focused on defining the role of epigenetic regulators and underlying mechanisms in cancer growth and progression.
 
Epigenetic alteration including DNA methylation, histone modification, nucleosome positioning and non-coding RNAs expression are involved in a complex network of regulating expression of oncogenes and tumor suppressor genes and constitute an important event of the multistep process of carcinogenesis. Recent advances in the understanding of the epigenetic regulation and detailed information of these epigenetic changes in various cancers provide new avenues of advancements in diagnostics, prognostics, and therapies of this highly fatal disease.

• DNA methylation
• Gene-expression control
• Histone modifications
• RNA expression
• Epigenetic regulators
• gene expression

• Department of Biological Sciences, Alabama State University, Montgomery, USA

  Manoj K. Mishra

• School of Medicine, Washington University, St. Louis, USA

  Kumar S. Bishnupuri

Manoj K. Mishra, Ph.D., is Associate Professor of Biology and founding Director of the cancer biology research and training program at Alabama State University. He has published over 25 articles, over 30 abstracts and poster exhibits, co-edited a book on Gene Regulation and Cancer, and has written over 5 book chapters. Dr. Mishra is on multiple ed boards, including the European Journal of Bioinformatics, Advances in Medical Informatics, and the International Journal of Experimental Medicine, to name a few.

Kumar S. Bishnupuri, Ph.D., is a Research Instructor in the Department of Medicine at Washington University School of Medicine. Dr. Bishnupuri has published over 16 articles, 4 book chapters, and 32 abstracts for conference symposia. He also serves as a scientific reviewer for several journals including Carcinogenesis, Frontiers in Bioscience, Cancer Biology and Therapy, Journal of Pathology, and more.

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