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Interleukin-27: Biological Properties and Clinical Application

  • Book
  • © 2016

Overview

Authors:
  1. Marek Jankowski

    1. Faculty of Medicine, Chair of Dermatolog, Nicolaus Copernicus University in Toruń, Bydgoszcz, Poland

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  2. Tomasz Wandtke

    1. Department of Gene Therapy, Nicolaus Copernicus University in Toruń, Bydgoszcz, Poland

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    You can also search for this author in PubMed   Google Scholar

Part of the book series: SpringerBriefs in Immunology (BRIEFSIMMUN)

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Table of contents (3 chapters)

  1. Front Matter

    Pages i-vi
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  2. IL-27: Structure, Regulation, and Variability

    • Marek Jankowski, Tomasz Wandtke
    Pages 1-25

  3. IL-27: A Key Player in Immune Regulation

    • Marek Jankowski, Tomasz Wandtke
    Pages 27-45

  4. IL-27 in Health and Disease

    • Marek Jankowski, Tomasz Wandtke
    Pages 47-86
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Keywords

About this book

This volume focuses on various aspects of interleukin-27 (IL-27), especially its potential for clinical applications. The authors discuss the downstream signaling from the IL-27 receptor and its molecular targets in immune cells including Th1, Th2, Th17, Treg, Tr1, Tfh, B cells, DCs and macrophages. The inhibition of Th17 cells by IL-27 is vital for the maintenance of the feto-maternal tolerance and the prevention of lupus, multiple sclerosis, autoimmune uveitis, immune thrombocytopenia and atherosclerosis. However, the same inhibitory capabilities compromise the immune response to bacterial pathogens, and IL-27 is a pathogenic factor in sepsis and tuberculosis. Also covered are the conflicting reports on the role of IL-27 in rheumatoid arthritis, the effect of IL-27 on epithelia, which seems to play a role in asthma, psoriasis and inflammatory bowel diseases, and the direct cytotoxic and anti-vascular effects of IL-27, which make it a promising agent for the treatment of cancer. Accordingly, this volume will be of interest to researchers and clinicians alike.

Authors and Affiliations

  • Faculty of Medicine, Chair of Dermatolog, Nicolaus Copernicus University in Toruń, Bydgoszcz, Poland

    Marek Jankowski

  • Department of Gene Therapy, Nicolaus Copernicus University in Toruń, Bydgoszcz, Poland

    Tomasz Wandtke

Bibliographic Information

  • Book Title: Interleukin-27: Biological Properties and Clinical Application

  • Authors: Marek Jankowski, Tomasz Wandtke

  • Series Title: SpringerBriefs in Immunology

  • DOI: https://doi.org/10.1007/978-3-319-39664-4

  • Publisher: Springer Cham

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: The Author(s) 2016

  • Softcover ISBN: 978-3-319-39662-0Published: 23 May 2016

  • eBook ISBN: 978-3-319-39664-4Published: 14 May 2016

  • Series ISSN: 2194-2773

  • Series E-ISSN: 2194-2781

  • Edition Number: 1

  • Number of Pages: VI, 86

  • Number of Illustrations: 5 illustrations in colour

  • Topics: Immunology, Cytokines and Growth Factors

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