Cdks and the Drosophila cell cycle

https://doi.org/10.1016/S0959-437X(97)80104-9Get rights and content

Abstract

Cyclin-dependent kinases play essential roles in driving the cell cycle. Much progress has been made in Drosophila over the past year in identifying the specific requirements for individual cyclins in particular cell cycle events. These studies encompass many aspects of the cell cycle, from the addition of a G1 phase to the cell cycle during embryogenesis to the role of cyclin degradation in progression through anaphase.

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      Although Cdk phosphorylation sites are not strictly conserved between yeast, Drosophila, Xenopus, and mammals, the relative arrangement of potential Cdk sites in subunits Orc1p and Orc2p is similar in all eukaryotes, suggesting that control of the ATPase activity of ORC through Cdk phosphorylation may be conserved in other eukaryotes (supplemental Fig. S5). Inhibition of the ability of DmORC to bind to DNA in an ATP-bound state provides an obvious mechanism by which Cdks could exert re-replication control in vivo and would be consistent with the requirement for alternating Cdk2·cyclin E activity during Drosophila endocycles and alternating Cdk activity during normal mitotic cycles (60–62). The ORCs from all species studied to date can bind to DNA in an ATP-independent mode, but for ScORC and DmORC the ATP-dependent interaction shows higher affinity.

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