Editors:
- Articles contributed by leading scientists in the field
- Discusses detailed molecular events leading to oncogenesis
- Useful for scientists of all levels
- Includes supplementary material: sn.pub/extras
Part of the book series: Subcellular Biochemistry (SCBI, volume 85)
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Table of contents (19 chapters)
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Front Matter
About this book
This book provides the readers with an overview of research on p53, which has been shown to play a role in numerous crucial biological pathways in normal and cancer cells. Leading scientist in the field, who have all made direct contributions to the understanding of the molecular events underpinning p53 function, have been invited to contribute the various chapters, which discuss the current knowledge of the signaling cascades that are activated by mutations in p53 and overexpression of MDM2, frequently found in human cancer and are major causes of oncogenesis.
This book features chapters on the molecular basis of oncogenesis induced by gain of function mutation of p53, signaling pathways induced by MDM2 overexpression, control of mutant or wild-type p53 function by MDM2 and MDMX, p53 mutation in hereditary cancer and structural aspects that activate mutant p53 which can be targeted by drug therapy. This book should be useful for scientists at all levels.
Editors and Affiliations
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Department of Biochemistry and Molecular Biology, and the Massey Cancer Center, Virginia Commonwealth University, Richmond, USA
Swati Palit Deb, Sumitra Deb
Bibliographic Information
Book Title: Mutant p53 and MDM2 in Cancer
Editors: Swati Palit Deb, Sumitra Deb
Series Title: Subcellular Biochemistry
DOI: https://doi.org/10.1007/978-94-017-9211-0
Publisher: Springer Dordrecht
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer Science+Business Media Dordrecht 2014
Hardcover ISBN: 978-94-017-9210-3Published: 22 September 2014
Softcover ISBN: 978-94-024-0357-2Published: 10 September 2016
eBook ISBN: 978-94-017-9211-0Published: 08 September 2014
Series ISSN: 0306-0225
Series E-ISSN: 2542-8810
Edition Number: 1
Number of Pages: VIII, 373
Number of Illustrations: 2 b/w illustrations, 36 illustrations in colour
Topics: Cancer Research, Cell Biology, Oncology